Larynx and hypopharynx
Other carcinoma
Neuroendocrine carcinoma

Author: Nat Pernick, M.D. (see Authors page)

Revised: 26 March 2018, last major update November 2013

Copyright: (c) 2002-2018,, Inc.

PubMed Search: Neuroendocrine carcinoma [title] larynx

Related Topics: Well differentiated neuroendocrine carcinoma, Moderately differentiated neuroendocrine carcinoma, Poorly differentiated neuroendocrine carcinoma

Cite this page: Pernick, N. Neuroendocrine carcinoma. website. Accessed August 16th, 2018.
Definition / general
  • Difficult to distinguish paraganglioma, carcinoid and small cell carcinoma in small biopsies without stains
  • Neuroendocrine carcinomas are most common nonsquamous carcinoma of larynx
  • Preferred terminology: well differentiated, moderately differentiated and poorly differentiated (small or large cell type) neuroendocrine carcinoma for carcinoid, atypical carcinoid, small cell undifferentiated and large cell undifferentiated carcinoma (Mod Pathol 2002;15:264)
  • Usually men ages 50 - 70 years, 2/3 are heavy smokers
  • Usually supraglottic
  • 43% have lymph nodal metastases
Prognostic factors
  • Poor prognostic factors: cervical nodal metastases, positive margins and vascular invasion
Gross description
  • Polypoid lesions 2 mm to 4 cm, arising in submucosa
Microscopic (histologic) description
  • Large polyhedral cells with hyperchromatic nuclei
  • Also anaplastic cells, areas of necrosis and mitotic figures
Positive stains
Electron microscopy description
  • Dense core neurosecretory granules