Larynx and hypopharynx
Other carcinoma
Small cell carcinoma




Topic Completed: 01 November 2013

Revised: 17 January 2019, last major update November 2013

Copyright: (c) 2002-2018, PathologyOutlines.com, Inc.

PubMed Search: Small cell carcinoma [title] larynx

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Cite this page: Pernick N. Small cell carcinoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/larynxsmallcell.html. Accessed January 19th, 2019.
Definition / general
  • Aggressive tumor with common cervical, nodal and distant metastases
  • Less than 0.5% of all cases
  • May be associated with squamous cell carcinoma
  • Usually age 50+, men and heavy smokers
Microscopic (histologic) description
  • Sheets of small to medium sized cells with minimal cytoplasm, hyperchromatic nuclei with no prominent nucleoli
  • Resembles lung tumor; may have foci of squamous or glandular differentiation
Positive stains
  • Variable neuroendocrine markers
Negative stains