Larynx and hypopharynx
Other carcinoma
Small cell carcinoma

Author: Nat Pernick, M.D. (see Authors page)

Revised: 26 March 2018, last major update November 2013

Copyright: (c) 2002-2018,, Inc.

PubMed Search: Small cell carcinoma [title] larynx

Cite this page: Pernick, N. Small cell carcinoma. website. Accessed October 16th, 2018.
Definition / general
  • Aggressive tumor with common cervical, nodal and distant metastases
  • Less than 0.5% of all cases
  • May be associated with squamous cell carcinoma
  • Usually age 50+, men and heavy smokers
Microscopic (histologic) description
  • Sheets of small to medium sized cells with minimal cytoplasm, hyperchromatic nuclei with no prominent nucleoli
  • Resembles lung tumor; may have foci of squamous or glandular differentiation
Positive stains
  • Variable neuroendocrine markers
Negative stains