Larynx and hypopharynx
Squamous cell carcinoma
Subglottic squamous cell carcinoma

Author: Nat Pernick, M.D. (see Authors page)

Revised: 23 March 2018, last major update November 2013

Copyright: (c) 2002-2018, PathologyOutlines.com, Inc.

PubMed Search: Squamous cell carcinoma [title] subglottic

Table of Contents
Definition / general | Treatment
Cite this page: Pernick, N. Subglottic squamous cell carcinoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/larynxsubglottic.html. Accessed July 22nd, 2018.
Definition / general
  • Also called infraglottic; by definition arise from region inferior to vocal cords to lower border of cricoid cartilage
  • Less than 5% of all cases; very rare to arise at this site; usually an extension of glottic tumor
  • May be defined to include glottic tumors with subglottic extension of 1 cm or more
  • Often spreads laterally to cricoid cartilage; often destroys interthyrocricoid membrane with invasion of prelaryngeal wall and thyroid gland
  • Cervical nodal metastases in 15%, paratracheal nodal metastases in 50%
Treatment
  • Excision with radical lymph node dissection