Leukemia - Acute
Acute lymphoblastic leukemia (ALL)
ALL with eosinophilia

Topic Completed: 1 February 2013

Revised: 22 January 2019, last major update February 2013

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PubMed Search: Acute lymphoblastic leukemia [title] eosinophilia

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Cite this page: Mihova D. ALL with eosinophilia. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/leukemiaALLeosinophil.html. Accessed November 18th, 2019.
Definition / general
  • Not part of WHO classification
  • ALL with marked eosinophilia is rare (< 50 cases reported through 2005) but may obscure ALL diagnosis
  • Symptoms are related to hypereosinophilia, including respiratory failure, myocardial infarction and cerebrovascular accident (Leuk Lymphoma 2005;46:1045)
  • Eosinophilia resolves with remission, returns with relapse
  • Eosinophilia is usually reactive, not part of leukemic cells
Case reports
  • Steroids suppress eosinophlia
Microscopic (histologic) images

Images hosted on other servers:
Missing Image

Bone marrow smear shows blasts,
eosinophilic myelocytes,
granulocytes and normoblasts

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CSF shows prominent eosinophilia,
basophilia and rare blasts (center)

Molecular / cytogenetics description
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