Leukemia - Acute
Acute lymphoblastic leukemia (ALL)
ALL with eosinophilia

Author: Daniela Mihova, M.D. (see Authors page)

Revised: 10 April 2018, last major update February 2013

Copyright: (c) 2001-2018, PathologyOutlines.com, Inc.

PubMed Search: Acute lymphoblastic leukemia [title] eosinophilia

Cite this page: Mihova, D. ALL with eosinophilia. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/leukemiaALLeosinophil.html. Accessed July 21st, 2018.
Definition / general
  • Not part of WHO classification
  • ALL with marked eosinophilia is rare (< 50 cases reported through 2005) but may obscure ALL diagnosis
  • Symptoms are related to hypereosinophilia, including respiratory failure, myocardial infarction and cerebrovascular accident (Leuk Lymphoma 2005;46:1045)
  • Eosinophilia resolves with remission, returns with relapse
  • Eosinophilia is usually reactive, not part of leukemic cells
Case reports
Treatment
  • Steroids suppress eosinophlia
Microscopic (histologic) images

Images hosted on other servers:
Missing Image

Bone marrow smear shows blasts,
eosinophilic myelocytes,
granulocytes and normoblasts

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CSF shows prominent eosinophilia,
basophilia and rare blasts (center)

Molecular / cytogenetics description