Leukemia - Acute
PreB ALL
B lymphoblastic leukemia / lymphoma with hyperdiploidy

Author: Daniela Mihova, M.D. (see Authors page)

Revised: 12 April 2018, last major update February 2013

Copyright: (c) 2001-2018, PathologyOutlines.com, Inc.

PubMed Search: B lymphoblastic leukemia lymphoma with hyperdiploidy [title]

Cite this page: Mihova, D. B lymphoblastic leukemia / lymphoma with hyperdiploidy. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/leukemiaALLhyperdiploidy.html. Accessed August 16th, 2018.
Definition / general
Microscopic (histologic) description
  • No distinct morphology
Molecular / cytogenetics description
  • Mutations in NRAS (10%), FLT3 (9%), PTPN11 (9%) and KRAS (6%, Genes Chromosomes Cancer 2008;47:26)
  • Most common extra copies are 21, X, 14 and 4; least often 1, 2, 3
  • Best prognosis of simultaneous trisomies: 4, 10 and 17