Bone marrow neoplastic
Bone marrow - plasma cell and lymphoid neoplasms
B lymphoblastic leukemia/lymphoma with recurrent genetic abnormalities
with hyperdiploidy


Topic Completed: 1 February 2013

Minor changes: 19 June 2020

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PubMed Search: B lymphoblastic leukemia lymphoma with hyperdiploidy [title]

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Cite this page: Mihova D. with hyperdiploidy. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/leukemiaALLhyperdiploidy.html. Accessed August 10th, 2020.
Definition / general
Microscopic (histologic) description
  • No distinct morphology
Molecular / cytogenetics description
  • Mutations in NRAS (10%), FLT3 (9%), PTPN11 (9%) and KRAS (6%, Genes Chromosomes Cancer 2008;47:26)
  • Most common extra copies are 21, X, 14 and 4; least often 1, 2, 3
  • Best prognosis of simultaneous trisomies: 4, 10 and 17
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