Bone marrow neoplastic

Bone marrow - plasma cell and lymphoid neoplasms

B lymphoblastic leukemia / lymphoma with recurrent genetic abnormalities

with hyperdiploidy



Last author update: 1 February 2013
Last staff update: 21 March 2022

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PubMed Search: B lymphoblastic leukemia lymphoma with hyperdiploidy [title]

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Cite this page: Mihova D. with hyperdiploidy. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/leukemiaALLhyperdiploidy.html. Accessed March 19th, 2024.
Definition / general
Microscopic (histologic) description
  • No distinct morphology
Molecular / cytogenetics description
  • Mutations in NRAS (10%), FLT3 (9%), PTPN11 (9%) and KRAS (6%, Genes Chromosomes Cancer 2008;47:26)
  • Most common extra copies are 21, X, 14 and 4; least often 1, 2, 3
  • Best prognosis of simultaneous trisomies: 4, 10 and 17
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