Leukemia - Acute
General
AML Classification

Author: Syed Zaidi, M.D. (see Authors page)

Revised: 28 March 2018, last major update December 2011

Copyright: (c) 2001-2018, PathologyOutlines.com, Inc.

PubMed Search: AML [title] Classification [title]

Cite this page: Zaidi, S. AML Classification. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/leukemiaAMLclass.html. Accessed August 20th, 2018.
Definition / general
  • French American British (FAB) classification system was used from 1976 to 2001, divided AML into M0 - M7 (Br J Haematol 1976;33:451)
  • WHO classification (2001 and revised in 2008) requires minimium of 20% of blasts in bone marrow or blood to diagnose AML (was 30% under FAB); eliminates myelodysplastic category of "refractory anemia with excess blasts in transformation" (Blood 2002;100:2292)
  • WHO classification also separates out AML "with recurrent genetic abnormalities" which have distinct clinical features


Acute myeloid leukemias with recurrent genetic abnormalities:
  • AML with t(8;21)(q22;q22); RUNX1-RUNX1T1
  • AML with inv(16)(p13.1;q22) or t(16;16)(p13.1;q22); CBF&beta-MYH11
  • Acute promyelocytic leukemia with t(15;17)(q22;q12); PML/RAR&alpha and variants
  • AML with t(9;11)(p22;q23); MLLT3-MLL
  • AML with t(6;9)(p23;q34); DEK-NUP214
  • AML with inv(3)(q21q26.2) or t(3;3)(q21;q26.2); RPN1-EVI1
  • AML (megakaryoblastic) with t(1;22)(p13;q13); RBM15-MKL1
  • AML with mutated NPM1*
  • AML with mutated CEBPA*

* provisional

Acute myeloid leukemia with myelodysplasia related changes

Therapy related acute myeloid leukemia
  • Alkylating agent related
  • Topoisomerase II inhibitor related (some maybe lymphoid)

Acute myeloid leukemia not otherwise categorized:
  • AML minimally differentiated (M0)
  • AML without maturation (M1)
  • AML with maturation (M2)
  • Acute myelomonocytic leukemia (M4)
  • Acute monoblastic and monocytic leukemia (M5a, M5b)
  • Acute erythroid leukemia (M6)
  • Acute megakaryoblastic leukemia (M7)
  • Acute basophilic leukemia
  • Acute panmyelosis with myelofibrosis

Myeloid Sarcoma

Myeloid proliferations related to Down syndrome:
  • Transient abnormal myelopoeisis
  • Myeloid leukemia associated with Down syndrome

Blastic plasmacytoid dentritic cell neoplasm

Acute leukemia of ambiguous lineage:
  • Acute undifferentiated leukemia
  • Mixed phenotype acute leukemia with t(9;22)(q34;q11.2); BCR-ABL1
  • Mixed phenotype acute leukemia with t(v;11q23); MLL rearranged
  • Mixed phenotype acute leukemia, B/myeloid, NOS
  • Mixed phenotype acute leukemia, T/myeloid, NOS
  • Mixed phenotype acute leukemia, NOS, rare types
  • Other acute leukemia of ambiguous lineage