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Leukemia - Acute

AML not otherwise categorized

AML with Philadelphia chromosome


Reviewer: Daniela Mihova, M.D. (see Reviewers page)
Revised: 1 February 2013, last major update September 2012
Copyright: (c) 2001-2013, PathologyOutlines.com, Inc.

General
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● Not part of WHO classification
● 1% of AML (Leuk Res 2004;28:579, Zhongguo Shi Yan Xue Ye Xue Za Zhi 2005;13:358), more common in bilineal, biphenotypic and acute basophilic leukemias
● Rarely is a secondary cytogenetic abnormality (Cancer Genet Cytogenet 2006;165:70)
● Compared to CML in blast crisis, has less frequent splenomegaly and peripheral basophilia, lower marrow cellularity and lower M/E ratios in marrow (Am J Clin Pathol 2007;127:642)
● Median survival 9 months
● Associated with poor prognosis in biphenotypic leukemia (Haematologica 1999;84:699)
● Philadelphia chromosome / translocation is t(9;22)(q34;q11), associated with CML (Wikipedia (Philadelphia chromosome))

Case reports
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● 44 year old man with dual presence of t(9;22) and inv(16) (Am J Clin Pathol 2006;125:260)
● Positive AML-M7 with extreme thrombocytosis and resistance to therapy (Ann Hematol 2004;83:381)

Treatment
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● Possibly imatinib, then allogeneic stem cell transplant (Eur J Haematol 2007;79:170)

Micro description
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● May occur in various AML subtypes

Micro images
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Fig A: hypercellular marrow (80%); fig B: mild increase in reticulin
Fig C: erythroid cells are dysplastic; fig D: CML


End of Leukemia - Acute > AML not otherwise categorized > AML with Philadelphia chromosome


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