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Leukemia - Acute

AML not otherwise categorized

CD13, CD33 negative


Reviewer: Daniela Mihova, M.D. (see Reviewers page)
Revised: 1 February 2013, last major update September 2012
Copyright: (c) 2001-2013, PathologyOutlines.com, Inc.

General
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● Not part of WHO classification
● Usually AML M1 or M2
● Typical myeloid morphology and cytochemistry, but negative for CD13, CD14, CD33, CD61 and glycophorin (Am J Clin Pathol 2000;114:29)
● Elderly patients negative for CD33 and CD34 have poor prognosis (Cancer 2008;112:572)
● May express CD13 or CD33 at relapse (Rinsho Ketsueki 2001;42:314, Intern Med 1993;32:733)
Caution: may induce CD13 expression with in vitro culture (Southeast Asian J Trop Med Public Health 2002;33 Suppl 2:155)

Molecular description
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● Often t(8;21)(q22;q22) (Am J Clin Pathol 1997;107:68, Ann Hematol 1999;78:237)

End of Leukemia - Acute > AML not otherwise categorized > CD13, CD33 negative


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