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Leukemia - Acute

AML not otherwise categorized

Hypocellular AML

Reviewer: Daniela Mihova, M.D. (see Reviewers page)
Revised: 2 February 2013, last major update September 2012
Copyright: (c) 2001-2013, PathologyOutlines.com, Inc.


● Defined as < 20% bone marrow cellularity, 20% or more are blasts (WHO); other definitions range up to 40% cellularity
● Up to 10% of AML cases
● Median age 67 years (Leuk Res 1996;20:563)
● Rare blasts in peripheral blood
● Often has smoldering course, although intensive chemotherapy may cause complete remission

Case reports

● 78 year old man and woman with minimally differentiated hypoplastic leukemia (Nihon Ronen Igakkai Zasshi 1997;34:70)

Micro images

Markedly hypocellular marrow in 57 year old man  Cells in interstitium are predominantly blasts
with severe pancytopenia and rare blasts in blood

Positive stains

● CD34, CD117, myeloperoxidase

Differential diagnosis

● Aplastic anemia: no excess blasts, interstitial bone marrow cells are plasma cells, lymphocytes and mast cells, not blasts
Refractory anemia with excess blasts
● Substance abuse: see Arch Pathol Lab Med 2005;129:e35

End of Leukemia - Acute > AML not otherwise categorized > Hypocellular AML

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