Leukemia acute
AML not otherwise categorized
Hypocellular AML



Topic Completed: 1 February 2013

Revised: 19 November 2019

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PubMed Search: Hypocellular AML


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Cite this page: Mihova D. Hypocellular AML. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/leukemiahypocellular.html. Accessed January 22nd, 2020.
Definition / general
  • Defined as < 20% bone marrow cellularity, 20% or more are blasts (WHO); other definitions range up to 40% cellularity
  • Up to 10% of AML cases
  • Median age 67 years (Leuk Res 1996;20:563)
  • Rare blasts in peripheral blood
  • Often has smoldering course although intensive chemotherapy may cause complete remission
Case reports
Microscopic (histologic) images
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Markedly hypocellular marrow
in 57 year old man with
severe pancytopenia and
rare blasts in blood

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Cells in interstitium are
predominantly blasts

Positive stains
Differential diagnosis
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