Leukemia - Acute
AML not otherwise categorized
Hypocellular AML




Topic Completed: 1 February 2013

Revised: 22 January 2019, last major update February 2013

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PubMed Search: Hypocellular AML

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Cite this page: Mihova D. Hypocellular AML. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/leukemiahypocellular.html. Accessed February 17th, 2019.
Definition / general
  • Defined as < 20% bone marrow cellularity, 20% or more are blasts (WHO); other definitions range up to 40% cellularity
  • Up to 10% of AML cases
  • Median age 67 years (Leuk Res 1996;20:563)
  • Rare blasts in peripheral blood
  • Often has smoldering course although intensive chemotherapy may cause complete remission
Case reports
Microscopic (histologic) images

Images hosted on PathOut server:
Missing Image

Markedly hypocellular marrow
in 57 year old man with
severe pancytopenia and
rare blasts in blood

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Cells in interstitium are
predominantly blasts

Positive stains
Differential diagnosis