Bone marrow neoplastic
Bone marrow - neoplastic myeloid
AML not otherwise specified
AML hypocellular


Topic Completed: 1 February 2013

Minor changes: 18 June 2020

Copyright: (c) 2001-2020, PathologyOutlines.com, Inc.

PubMed Search: Hypocellular AML


Page views in 2019: 218
Page views in 2020 to date: 236
Cite this page: Mihova D. AML hypocellular. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/leukemiahypocellular.html. Accessed November 23rd, 2020.
Definition / general
  • Defined as < 20% bone marrow cellularity, 20% or more are blasts (WHO); other definitions range up to 40% cellularity
  • Up to 10% of AML cases
  • Median age 67 years (Leuk Res 1996;20:563)
  • Rare blasts in peripheral blood
  • Often has smoldering course although intensive chemotherapy may cause complete remission
Case reports
Microscopic (histologic) images
Missing Image

Markedly hypocellular marrow
in 57 year old man with
severe pancytopenia and
rare blasts in blood

Missing Image

Cells in interstitium are
predominantly blasts

Positive stains
Differential diagnosis
Back to top
Image 01 Image 02