Home   Chapter Home   Jobs   Conferences   Fellowships   Books



Advertisement

Leukemia - Acute

AML not otherwise categorized

Hypocellular AML


Reviewer: Daniela Mihova, M.D. (see Reviewers page)
Revised: 2 February 2013, last major update September 2012
Copyright: (c) 2001-2013, PathologyOutlines.com, Inc.

General
=========================================================================

● Defined as < 20% bone marrow cellularity, 20% or more are blasts (WHO); other definitions range up to 40% cellularity
● Up to 10% of AML cases
● Median age 67 years (Leuk Res 1996;20:563)
● Rare blasts in peripheral blood
● Often has smoldering course, although intensive chemotherapy may cause complete remission

Case reports
=========================================================================

● 78 year old man and woman with minimally differentiated hypoplastic leukemia (Nihon Ronen Igakkai Zasshi 1997;34:70)

Micro images
=========================================================================


                 
Markedly hypocellular marrow in 57 year old man  Cells in interstitium are predominantly blasts
with severe pancytopenia and rare blasts in blood

Positive stains
=========================================================================

● CD34, CD117, myeloperoxidase

Differential diagnosis
=========================================================================

● Aplastic anemia: no excess blasts, interstitial bone marrow cells are plasma cells, lymphocytes and mast cells, not blasts
Refractory anemia with excess blasts
● Substance abuse: see Arch Pathol Lab Med 2005;129:e35

End of Leukemia - Acute > AML not otherwise categorized > Hypocellular AML


This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.

All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com with any questions (click here for other contact information).