Leukemia - acute
PreB ALL
Mature B cell ALL




Topic Completed: 1 November 2014

Revised: 22 January 2019, last major update November 2014

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PubMed Search: Mature b cell acute lymphoblastic leukemia [title]

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Cite this page: Mihova D. Mature B cell ALL. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/leukemiamatureBAll.html. Accessed April 23rd, 2019.
Definition / general
  • Also called Burkitt leukemia, FAB L3
  • See also Lymphoma and plasma cell neoplasms chapter
  • WHO classifies Burkitt lymphoma with secondary marrow or peripheral blood involvement and ALL-L3 as same disease
  • Variants are endemic, sporadic and immunodeficiency associated with different clinical and geographic presentations
  • Extramedullary masses are prominent, often the presenting feature
  • Pure leukemic involvement is rare
  • Cases with mature B phenotype but no c-myc translocations are best classified and managed as pre-B ALL (Arch Pathol Lab Med 2003;127:1340)
Case reports
Treatment
  • More intensive chemotherapy than standard ALL plus CNS prophylaxis; overall survival up to 50 - 70% in adults (Blood 2004;104:3009)
Microscopic (histologic) description
  • Intermediate to large blasts with intensely basophilic cytoplasm containing prominent vacuoles, nuclei are round with coarse / mildly clumped chromatin and indistinct nucleoli
  • Low power has starry sky appearance in biopsies
Microscopic (histologic) images

Images hosted on other servers:
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Peripheral blood (fig 1A), bone marrow
aspirate (fig 1B), bone marrow biopsy
(fig 2) and inset-CD20



Peripheral blood smears:


Stains:
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Oil Red O+

Positive stains
Negative stains
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