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Leukemia - Acute

PreB ALL

B lymphoblastic leukemia / lymphoma with t(5;14)(q31;q32); IL3-IGH


Reviewer: Daniela Mihova, M.D. (see Reviewers page)
Revised: 2 February 2013, last major update September 2012
Copyright: (c) 2001-2013, PathologyOutlines.com, Inc.

General
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● Diagnosis based on immunophenotype and genetic findings, even with low blast count
● Very rare; < 1% of all ALL; both children and adults (Blood 1989;73:2081)
● Presents with variable eosinophilia; may be asymptomatic and lack any blasts (Medicine (Baltimore) 1990;69:232)

Case reports
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● 13 year old boy with cardiac disease (BMJ Case Rep 2012 Jan 20;2012)
● CD10+ acute leukemia with t(5q;14q) translocation and hypereosinophilia (Acta Haematol 1989;82:85)

Micro description
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● CD19+ CD10+ lymphoblasts with circulating reactive eosinophils

Micro images
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Reactive eosinophilia in ALL patient

Molecular description
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● t(5;14)(q31;q32); IL3-IGH (Atlas Genet Cytogenet Oncol Haematol September 2011)

End of Leukemia - Acute > PreB ALL > B lymphoblastic leukemia / lymphoma with t(5;14)(q31;q32); IL3-IGH


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