Leukemia acute
Recurrent genetic abnormalities
Acute promyelocytic leukemia - therapy related

Topic Completed: 1 February 2013

Revised: 15 November 2019

Revised: 22 January 2019, last major update February 2013

Copyright: (c) 2001-2019, PathologyOutlines.com, Inc.

PubMed Search: Acute promyelocytic leukemia therapy related [title]

Syed Zaidi, M.D.
Page views in 2018: 53
Page views in 2019 to date: 122
Cite this page: Zaidi S. Acute promyelocytic leukemia - therapy related. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/leukemiatherapyAPL.html. Accessed November 15th, 2019.
Definition / general
  • Not a WHO diagnosis
  • Prior tumor is usually breast carcinoma, other solid tumor or non-Hodgkin lymphoma treated with radiation or chemotherapy (J Clin Oncol 2003;21:2123)
  • Usually develops within 3 years with no preleukemic phase
  • Mitoxantrone, etoposide or their metabolites stimulate topoisomerase II to cleave different sites in PML and RARA, which are then translocated (N Engl J Med 2005;352:1529)
Diagrams / tables

Images hosted on other servers:
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Breakpoint Hot Spot in PML Intron 6 in Mitoxantrone-Related APL

Case reports
Microscopic (histologic) description
  • Classic findings of APL plus dyserythropoiesis and dysmegakaryopoiesis
Molecular / cytogenetics description
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