Leukemia - Acute
Recurrent genetic abnormalities
Acute promyelocytic leukemia - therapy related

Author: Syed Zaidi, M.D. (see Authors page)

Revised: 3 April 2018, last major update February 2013

Copyright: (c) 2001-2018, PathologyOutlines.com, Inc.

PubMed Search: Acute promyelocytic leukemia therapy related [title]

Cite this page: Zaidi, S. Acute promyelocytic leukemia - therapy related. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/leukemiatherapyAPL.html. Accessed August 20th, 2018.
Definition / general
  • Not a WHO diagnosis
  • Prior tumor is usually breast carcinoma, other solid tumor or non-Hodgkin lymphoma treated with radiation or chemotherapy (J Clin Oncol 2003;21:2123)
  • Usually develops within 3 years with no preleukemic phase
Pathophysiology
  • Mitoxantrone, etoposide or their metabolites stimulate topoisomerase II to cleave different sites in PML and RARA, which are then translocated (N Engl J Med 2005;352:1529)
Diagrams / tables

Images hosted on other servers:
Missing Image

Breakpoint Hot Spot in PML Intron 6 in Mitoxantrone-Related APL

Case reports
Microscopic (histologic) description
  • Classic findings of APL plus dyserythropoiesis and dysmegakaryopoiesis
Molecular / cytogenetics description