Liver and intrahepatic bile ducts-nontumor - HHV6 (human herpes virus 6)

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Liver and intrahepatic bile ducts-nontumor

Viral hepatitis

HHV6 (human herpes virus 6)

Reviewers: Komal Arora, M.D. (see Reviewers page)
Revised: 9 May 2012, last major update May 2012
Copyright: (c) 2004-2012, PathologyOutlines.com, Inc.

General
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● Infections occur in > 95% of humans; primary infection occurs in early childhood as asymptomatic illness or clinically as roseola infantum (exanthum subitum / HHV6B), leads to subclinical viral persistence and latency; rarely hepatitis, meningoencephalitis or febrile convulsions
● Reactivation of latent HHV6 is common after liver transplantation, possibly induced and facilitated by allograft rejection and immunosuppressive therapy (World J Gastroenterol 2009;15:2561)
● High intrahepatic HHV-6 virus loads are associated with decreased graft survival after diagnosis of graft hepatitis (J Hepatol 2012;56:1)

Case reports
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● 8 month old boy with fulminant hepatic failure due to HHV-6 infection (Hum Pathol 2001;32:887)
● 18 year old immunocompetent woman presenting with sever jaundice and liver dysfunction (Cases J 2008;1:110)

Micro description
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● Panlobular microvesicular steatosis in glycogen-depleted hepatocytes resembling Reye’s syndrome, eosinophilic central hepatocytes, with some nuclear disappearance
● Minimal inflammation, no changes in portal areas

Micro images
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Cervical lymph node and liver

Electron microscopy images
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Cervical lymph node

End of Liver and intrahepatic bile ducts-nontumor > Viral hepatitis > HHV6 (human herpes virus 6)

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