Cite this page: Arora K. HHV6 (human herpesvirus 6). PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/liverHHV6.html. Accessed March 31st, 2020.
Definition / general
- Infections occur in > 95% of humans; primary infection occurs in early childhood as asymptomatic illness or clinically as roseola infantum (exanthum subitum / HHV6B), leads to subclinical viral persistence and latency; rarely hepatitis, meningoencephalitis or febrile convulsions
- Reactivation of latent HHV6 is common after liver transplantation, possibly induced and facilitated by allograft rejection and immunosuppressive therapy (World J Gastroenterol 2009;15:2561)
- High intrahepatic HHV6 virus loads are associated with decreased graft survival after diagnosis of graft hepatitis (J Hepatol 2012;56:1063)
Microscopic (histologic) description
- Panlobular microvesicular steatosis in glycogen depleted hepatocytes resembling Reye syndrome, eosinophilic central hepatocytes, with some nuclear disappearance
- Minimal inflammation, no changes in portal areas