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Liver and intrahepatic bile ducts-nontumor

Metabolic diseases

Heme oxygenase-1 deficiency


Reviewers: Komal Arora, M.D. (see Reviewers page)
Revised: 30 April 2012, last major update April 2012
Copyright: (c) 2004-2012, PathologyOutlines.com, Inc.

General
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● Enzyme degrades heme into biliverdin, carbon monoxide and free iron; also is anti-oxidant, and has role in iron balance (J Cell Mol Med 2009;13:3091)

Case reports
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● 6 year old boy with growth retardation, anemia, other laboratory abnormalities (Hum Pathol 2002;33:125)

Micro description
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● Amyloid present in liver and adrenal glands, mesangioproliferative glomerular changes in kidney, fatty streaks and fibrous plaques in aorta

End of Liver and intrahepatic bile ducts-nontumor > Metabolic diseases > Heme oxygenase-1 deficiency


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