Cite this page: Arora K. Heme oxygenase-1 deficiency. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/liverHO1deficiency.html. Accessed February 18th, 2020.
Definition / general
- Enzyme degrades heme into biliverdin, carbon monoxide and free iron; also is antioxidant and has role in iron balance (J Cell Mol Med 2009;13:3091)
- 6 year old boy with growth retardation, anemia, other laboratory abnormalities (Hum Pathol 2002;33:125)
Microscopic (histologic) description
- Amyloid present in liver and adrenal glands, mesangioproliferative glomerular changes in kidney, fatty streaks and fibrous plaques in aorta