Liver & intrahepatic bile ducts nontumor
Liver transplantation early onset graft injury
Post liver transplant lymphoproliferative disorder

Topic Completed: 1 May 2012

Revised: 23 January 2019, last major update May 2012

Copyright: (c) 2002-2017,, Inc.

PubMed Search: Posttransplant lymphoproliferative disorder[TI] liver[TI]

Komal Arora, M.D.
Page views in 2019: 67
Page views in 2020 to date: 60
Cite this page: Arora K. Post liver transplant lymphoproliferative disorder. website. Accessed July 4th, 2020.
Definition / general
  • Due to immunosuppressive drugs for solid organ transplantation (including liver), particularly cyclosporine
  • Usually presents at 6 - 17 months posttransplant as systemic illness; only 2 - 3% of liver grafts are involved
  • Tumors usually of host origin
  • Strongly associated with EBV
  • Also associated with acute rejection in 80% of biopsies, which can be treated even if EBV present (Am J Surg Pathol 2001;25:324, Am J Surg Pathol 2006;30:1604)
Case reports
Microscopic (histologic) description
  • Early lesions: formerly called plasmacytic hyperplasia; infectious mononucleosis-like, composed of small lymphocytes, plasma cells, scattered immunoblasts
  • Polymorphic lesions: medium sized lymphocytes with mitotic activity, plasma cells, immunoblasts
  • Monomorphic lesions: resemble high grade lymphoma; most cells are large and plant-like
Microscopic (histologic) images

Images hosted on other servers:

H&E, CD20, EBV

Additional references
Pediatric cases
Definition / general
  • All cases related to EBV
  • Often involves Waldeyer ring
  • Favorable prognosis for early lesions and nonmalignant lesions (polymorphous subtype)
  • Malignant lesions often diffuse large B cell lymphoma
  • Poor prognostic factors: 3+ sites of involvement, allograft involvement

Microscopic (histologic) images

Images hosted on other servers:

Infectious mononucleosis-like lesion

Polymorphous subtype with
monotypic light chain
expression, EBV+, diffuse large
B cell lymphoma-like lesion

Additional references
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