Liver and intrahepatic bile ducts-nontumor

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Liver and intrahepatic bile ducts-nontumor

Vascular disorders

Veno-occlusive disease

Reviewers: Komal Arora, M.D. (see Reviewers page)
Revised: 16 May 2012, last major update May 2012
Copyright: (c) 2004-2012, PathologyOutlines.com, Inc.

General
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● Originally in Jamaican drinkers of pyrrolizidine alkaloid-containing bush tea
● Now occurs after a few weeks in 25% with allogeneic bone marrow transplant; 30% mortality; biopsy is risky in these patients
● Symptoms: tender hepatomegaly, ascites, weight gain, jaundice
● Treatment: supportive

Case reports
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● 37 year old woman with recurrent progressive fibro-obliterative venopathy after liver transplant (Am J Surg Pathol 1999;23:734)

Micro description
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● Obliteration of central vein (terminal hepatic venule) radicles by subendothelial swelling and fine reticulated collagen
● Acutely is centrilobular congestion/necrosis with hemosiderin laden macrophages
● Later, obliteration of lumen is noted with reticulin stain; very late - may see obliteration of the venule

Micro images
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Fibrous occlusion of centrilobular venule (silver stain)

End of Liver and intrahepatic bile ducts-nontumor > Vascular disorders > Veno-occlusive disease

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