Liver and intrahepatic bile ducts - nontumor
Acute graft rejection

Topic Completed: 1 May 2012

Revised: 5 August 2019

Copyright: (c) 2002-2018,, Inc.

PubMed Search: Acute rejection[TI] liver[TI] free full text[sb]

Komal Arora, M.D.
Page views in 2018: 1,170
Page views in 2019 to date: 1,241
Cite this page: Arora K. Acute graft rejection. website. Accessed September 23rd, 2019.
Definition / general
  • Cautious increase in immunosuppression (even if posttransplant lymphoproliferative disorder)
Microscopic (histologic) description
  • Portal infiltrate of lymphocytes and variable eosinophils and neutrophils that damage bile ducts and venous endothelium
  • No / minimal hepatocyte damage
  • Also loss of bile ducts, arteritis, central ischemic damage with ballooning degeneration and hepatocyte dropout
Microscopic (histologic) images

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Moderate acute rejection with bile duct damage

Severe acute rejection

Loss of bile ducts

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