Liver and intrahepatic bile ducts-nontumor
Reviewers: Komal Arora, M.D. (see Reviewers page)
Revised: 18 May 2012, last major update May 2012
Copyright: (c) 2004-2012, PathologyOutlines.com, Inc.
● Liver involvement in primary or secondary amyloidosis
● Usually AL type (Pathologe 2009;30:240)
● 55 year old woman with systemic AL amyloidosis undergoing treatment with high-dose melphalan and autologous stem cell transplantation who died due to spontaneous hepatic rupture (Amyloid 2009;16:103)
● Associated with primary sclerosing cholangitis (Eur J Gastroenterol Hepatol 2010;22:1265)
Spontaneous rupture of liver associated with treatment for systemic AL amyloidosis
● Amyloid deposition in blood vessels and sinusoids, leading to atrophic hepatocyte cell plates
● May have pericellular fibrosis
AL (systemic) amyloidosis
Apolipoprotein A-I amyloidosis
Myeloma associated amyloidosis
Portal arteriole: sulfated alcian blue stain
● Congo red (apple green birefringence with polarized microscopy)
End of Liver and intrahepatic bile ducts-nontumor > Systemic disease/conditions > Amyloidosis
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