Liver and intrahepatic bile ducts-nontumor

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Liver and intrahepatic bile ducts-nontumor

Systemic disease/conditions

Amyloidosis

Reviewers: Komal Arora, M.D. (see Reviewers page)
Revised: 18 May 2012, last major update May 2012
Copyright: (c) 2004-2012, PathologyOutlines.com, Inc.

General
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● Liver involvement in primary or secondary amyloidosis
● Usually AL type (Pathologe 2009;30:240)

Case reports
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● 55 year old woman with systemic AL amyloidosis undergoing treatment with high-dose melphalan and autologous stem cell transplantation who died due to spontaneous hepatic rupture (Amyloid 2009;16:103)
● Associated with primary sclerosing cholangitis (Eur J Gastroenterol Hepatol 2010;22:1265)

Gross images
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Spontaneous rupture of liver associated with treatment for systemic AL amyloidosis

Micro description
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● Amyloid deposition in blood vessels and sinusoids, leading to atrophic hepatocyte cell plates
● May have pericellular fibrosis

Micro images
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AL (systemic) amyloidosis

Apolipoprotein A-I amyloidosis

Myeloma associated amyloidosis

Portal arteriole: sulfated alcian blue stain

Cytology images
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Amyloidosis

Positive stains
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● Congo red (apple green birefringence with polarized microscopy)

End of Liver and intrahepatic bile ducts-nontumor > Systemic disease/conditions > Amyloidosis

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