Liver and intrahepatic bile ducts - nontumor
Metabolic diseases
Familial apolipoprotein A-I amyloidosis

Topic Completed: 1 April 2012

Revised: 20 January 2020

Copyright: 2002-2020,, Inc.

PubMed Search: Familial apolipoprotein A-I amyloidosis

Komal Arora, M.D.
Page views in 2019: 159
Page views in 2020 to date: 50
Cite this page: Arora K. Familial apolipoprotein A-I amyloidosis. website. Accessed March 28th, 2020.
Definition / general
  • Apo A-I is major protein constituent of plasma high density lipoprotein; is synthesized in liver and intestine
  • At least 10 different amyloidogenic apo A-I mutations exist
Case reports
  • Liver transplant slows disease progression
Microscopic (histologic) description
  • Often striking liver parenchymal involvement by large patches of amyloid replacing hepatic lobules, separating hepatic cords, accentuation around central veins, involving portal triads, hilar soft tissue
  • No involvement of hilar nerve branches or vagus nerve
Positive stains
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