Liver and intrahepatic bile ducts - nontumor
Metabolic diseases
Familial apolipoprotein A-I amyloidosis

Author: Komal Arora, M.D. (see Authors page)

Revised: 14 November 2017, last major update April 2012

Copyright: (c) 2002-2017,, Inc.

PubMed Search: Familial apolipoprotein A-I amyloidosis

Cite this page: Arora, K. Familial apolipoprotein A-I amyloidosis. website. Accessed September 25th, 2018.
Definition / general
  • Apo A-I is major protein constituent of plasma high density lipoprotein; is synthesized in liver and intestine
  • At least 10 different amyloidogenic apo A-I mutations exist
Case reports
  • Liver transplant slows disease progression
Microscopic (histologic) description
  • Often striking liver parenchymal involvement by large patches of amyloid replacing hepatic lobules, separating hepatic cords, accentuation around central veins, involving portal triads, hilar soft tissue
  • No involvement of hilar nerve branches or vagus nerve
Positive stains