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Liver and intrahepatic bile ducts-nontumor

Vascular disorders

Arterial disorders


Reviewers: Komal Arora, M.D. (see Reviewers page)
Revised: 19 May 2012, last major update May 2012
Copyright: (c) 2004-2012, PathologyOutlines.com, Inc.

General
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● Rare; difficult to diagnose clinically
● Hepatic artery occulsion due to emboli, neoplasia, polyarteritis nodosa, trauma, sepsis; clinically presents with severe abdominal pain, high ALT/AST, variable circulatory shock
● May cause local infarct of Zahn (sharply demarcated, anemic, pale tan or hemorrhagic area due to portal blood), although retrograde arterial flow through accessory vessels and portal supply may sustain liver parenchyma
● In transplanted liver, hepatic artery thrombosis may cause loss of organ, since there is no portal supply (Am J Transplant 2012 Mar 5 [Epub ahead of print])
● Takayasu arteritis may be associated with hepatic sinusoidal dilatation (Ann Hepatol 2011;10:559)

Micro description
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● Ischemia causes centrilobular or random necrosis
● May have coagulative necrosis or ballooning degeneration with hepatocyte dropout

End of Liver and intrahepatic bile ducts-nontumor > Vascular disorders > Arterial disorders


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