Liver and intrahepatic bile ducts - nontumor
Infectious (nonviral) disorders
Bacterial infections

Topic Completed: 1 May 2012

Revised: 1 November 2017, last major update May 2012

Copyright: (c) 2002-2017,, Inc.

PubMed Search: Bacterial infections[TI] liver[TI]

See also: Liver - pyogenic abscess

Komal Arora, M.D.
Page views in 2019: 401
Page views in 2020 to date: 78
Cite this page: Arora K. Bacterial infections. website. Accessed February 20th, 2020.
Definition / general
Cholestasis of sepsis
Definition / general
  • Usually gram negative sepsis
  • Diagnosis of exclusion

Microscopic (histologic) description
  • Canalicular cholestasis, neutrophils in sinusoids, variable cholangiolar cholestasis

Microscopic (histologic) images

Images hosted on other servers:

Ductular cholestasis

Differential diagnosis
Bacterial infection of liver
Definition / general
  • Various bacterial species, including atypical mycobacteria (smaller epithelioid granulomas), Bartonella henselae (vascular proliferation simulates Kaposi sarcoma or peliosis), Brucella (poorly formed sinusoidal granulomas), Listeria (poorly formed sinusoidal granulomas), Mycobacterium tuberculosis (giant cell granulomas with variable necrosis), congenital syphilis (pericellular fibrosis), Salmonella typhi (typhoid fever), Staphylococcus aureus (toxic shock syndrome)

Microscopic (histologic) description
  • Sepsis in ICU patients: centrilobular necrosis (80%), steatosis (73%), portal inflammation (73%), lobular inflammation (67%), hepatocellular apoptosis (67%), cholangitis / cholangiolitis (20%) (World J Gastroenterol 2008;14:1389)

Microscopic (histologic) images

Images hosted on other servers:

Liver biopsies in patients dying of sepsis

Back to top