Liver and intrahepatic bile ducts - nontumor
Infectious (nonviral) disorders
Bacterial infections

Author: Komal Arora, M.D. (see Authors page)

Revised: 1 November 2017, last major update May 2012

Copyright: (c) 2002-2017, PathologyOutlines.com, Inc.

PubMed Search: Bacterial infections[TI] liver[TI]

See also: Liver - pyogenic abscess
Cite this page: Arora, K. Bacterial infections. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/liverbacteria.html. Accessed November 20th, 2017.
Definition / general
Cholestasis of sepsis
Definition / general
  • Usually gram negative sepsis
  • Diagnosis of exclusion


Microscopic (histologic) description
  • Canalicular cholestasis, neutrophils in sinusoids, variable cholangiolar cholestasis


Microscopic (histologic) images

Images hosted on other servers:

Ductular cholestasis



Differential diagnosis
Bacterial infection of liver
Definition / general
  • Various bacterial species, including atypical mycobacteria (smaller epithelioid granulomas), Bartonella henselae (vascular proliferation simulates Kaposi sarcoma or peliosis), Brucella (poorly formed sinusoidal granulomas), Listeria (poorly formed sinusoidal granulomas), Mycobacterium tuberculosis (giant cell granulomas with variable necrosis), congenital syphilis (pericellular fibrosis), Salmonella typhi (typhoid fever), Staphylococcus aureus (toxic shock syndrome)


Microscopic (histologic) description
  • Sepsis in ICU patients: centrilobular necrosis (80%), steatosis (73%), portal inflammation (73%), lobular inflammation (67%), hepatocellular apoptosis (67%), cholangitis / cholangiolitis (20%) (World J Gastroenterol 2008;14:1389)


Microscopic (histologic) images

Images hosted on other servers:

Liver biopsies in patients dying of sepsis