Liver and intrahepatic bile ducts-nontumor
Infectious (non-viral) disorders
Reviewers: Komal Arora, M.D. (see Reviewers page)
Revised: 27 June 2012, last major update May 2012
Copyright: (c) 2004-2012, PathologyOutlines.com, Inc.
See also Liver-pyogenic abscess
● Causes large numbers of deaths in patients with liver disease (Int J Hepatol 2011;2011:784540)
● Due to cholestasis of sepsis, ascending cholangitis, post-transplant infection (Liver Transpl 2012;18:468)
or other bacterial infection of liver
Cholestasis of sepsis
● Usually gram negative sepsis
● Diagnosis of exclusion
● Canalicular cholestasis, neutrophils in sinusoids, variable cholangiolar cholestasis
● Cholestatic drug reaction, early biliary obstruction (portal involvement), postoperative cholestasis, familial cholestatic syndromes
Bacterial infection of liver
● Various bacterial species, including atypical mycobacteria (smaller epithelioid granulomas), Bartonella henselae (vascular proliferation simulates Kaposiís sarcoma or peliosis), Brucella (poorly formed sinusoidal granulomas), Listeria (poorly formed sinusoidal granulomas), Mycobacteria tuberculosis (giant cell granulomas with variable necrosis), congenital syphilis (pericellular fibrosis), Salmonella typhi (typhoid fever), Staphylococcus aureus (toxic shock syndrome)
● Sepsis in ICU patients: centrilobular necrosis (80%), steatosis (73%), portal inflammation (73%), lobular inflammation (67%), hepatocellular apoptosis (67%), cholangitis/cholangiolitis (20%, World J Gastroenterol 2008;14:1389)
Liver biopsies in patients dying of sepsis
End of Liver and intrahepatic bile ducts-nontumor > Infectious (non-viral) disorders > Bacterial infections
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