Liver and intrahepatic bile ducts - nontumor
Transplantation
Chronic graft versus host disease (GVHD)



Topic Completed: 1 May 2012

Revised: 23 January 2019, last major update May 2012

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PubMed Search: Chronic graft versus host disease[TI] liver[TI]


Komal Arora, M.D.
Page views in 2018: 331
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Cite this page: Arora K. Chronic graft versus host disease (GVHD). PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/liverchronicGVHD.html. Accessed October 17th, 2019.
Definition / general
  • Changes occurring after posttransplant day #100
  • Biopsy provides diagnosis and prognostic information
  • Poor prognostic features: piecemeal necrosis, fibrosis, cirrhosis
Microscopic (histologic) description
  • Brisk lymphocytic infiltrate, bile duct damage with total loss of interlobular bile ducts (vanishing bile duct syndrome), endothelialitis
  • May be piecemeal necrosis but no extensive hepatocellular damage
Differential diagnosis
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