Liver and intrahepatic bile ducts - nontumor
Chronic graft versus host disease (GVHD)

Author: Komal Arora, M.D. (see Authors page)

Revised: 13 November 2017, last major update May 2012

Copyright: (c) 2002-2017,, Inc.

PubMed Search: Chronic graft versus host disease[TI] liver[TI]

Cite this page: Arora, K. Chronic graft versus host disease (GVHD). website. Accessed May 22nd, 2018.
Definition / general
  • Changes occurring after posttransplant day #100
  • Biopsy provides diagnosis and prognostic information
  • Poor prognostic features: piecemeal necrosis, fibrosis, cirrhosis
Microscopic (histologic) description
  • Brisk lymphocytic infiltrate, bile duct damage with total loss of interlobular bile ducts (vanishing bile duct syndrome), endothelialitis
  • May be piecemeal necrosis but no extensive hepatocellular damage
Differential diagnosis