Liver and intrahepatic bile ducts - nontumor
Chronic graft versus host disease (GVHD)

Topic Completed: 1 May 2012

Revised: 23 January 2019, last major update May 2012

Copyright: (c) 2002-2017,, Inc.

PubMed Search: Chronic graft versus host disease[TI] liver[TI]

Komal Arora, M.D.
Page views in 2019: 424
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Cite this page: Arora K. Chronic graft versus host disease (GVHD). website. Accessed February 27th, 2020.
Definition / general
  • Changes occurring after posttransplant day #100
  • Biopsy provides diagnosis and prognostic information
  • Poor prognostic features: piecemeal necrosis, fibrosis, cirrhosis
Microscopic (histologic) description
  • Brisk lymphocytic infiltrate, bile duct damage with total loss of interlobular bile ducts (vanishing bile duct syndrome), endothelialitis
  • May be piecemeal necrosis but no extensive hepatocellular damage
Differential diagnosis
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