Liver and intrahepatic bile ducts - nontumor
Biliary tract disease
Chronic large duct obstruction

Topic Completed: 1 May 2012

Revised: 25 April 2019

Revised: 23 January 2019, last major update May 2012

Copyright: (c) 2002-2017,, Inc.

PubMed Search: Chronic large duct obstruction liver

Komal Arora, M.D.
Page views in 2018: 679
Page views in 2019 to date: 333
Cite this page: Arora K. Chronic large duct obstruction. website. Accessed June 25th, 2019.
  • Impacted stones, recurrent passed stones, biliary fibrosis, primary sclerosing cholangitis
Microscopic (histologic) description
  • Diffuse bile ductular proliferation with more fibrosis than acute cases
  • Also primarily chronic inflammatory infiltrate, onion skin cuffing of fibroblasts around large bile ducts, variable cholestasis, variable Mallory hyaline in periportal hepatocytes
  • Usually no edema, minimal neutrophils, minimal interlobular bile ducts
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