Liver and intrahepatic bile ducts-nontumor - Chronic large duct obstruction

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Liver and intrahepatic bile ducts-nontumor

Biliary tract disease

Chronic large duct obstruction

Reviewers: Komal Arora, M.D. (see Reviewers page)
Revised: 12 May 2012, last major update May 2012
Copyright: (c) 2004-2012, PathologyOutlines.com, Inc.

Causes
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● Impacted stones, recurrent passed stones, biliary fibrosis, primary sclerosing cholangitis

Micro description
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● Diffuse bile ductular proliferation with more fibrosis than acute cases
● Also primarily chronic inflammatory infiltrate, onion skin cuffing of fibroblasts around large bile ducts, variable cholestasis, variable Mallory’s hyaline in periportal hepatocytes
● Usually no edema, minimal neutrophils, minimal interlobular bile ducts

Differential diagnosis
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● Hepatitis C, primary sclerosing cholangitis, primary biliary cirrhosis

End of Liver and intrahepatic bile ducts-nontumor > Biliary tract disease > Chronic large duct obstruction

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