Cite this page: Arora K. Chronic large duct obstruction. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/liverchroniclargeductobstruction.html. Accessed February 21st, 2019.
- Impacted stones, recurrent passed stones, biliary fibrosis, primary sclerosing cholangitis
Microscopic (histologic) description
- Diffuse bile ductular proliferation with more fibrosis than acute cases
- Also primarily chronic inflammatory infiltrate, onion skin cuffing of fibroblasts around large bile ducts, variable cholestasis, variable Mallory hyaline in periportal hepatocytes
- Usually no edema, minimal neutrophils, minimal interlobular bile ducts