Liver and intrahepatic bile ducts - nontumor
Biliary tract disease
Chronic large duct obstruction

Author: Komal Arora, M.D. (see Authors page)

Revised: 7 November 2017, last major update May 2012

Copyright: (c) 2002-2017,, Inc.

PubMed Search: Chronic large duct obstruction liver

Cite this page: Arora, K. Chronic large duct obstruction. website. Accessed March 19th, 2018.
  • Impacted stones, recurrent passed stones, biliary fibrosis, primary sclerosing cholangitis
Microscopic (histologic) description
  • Diffuse bile ductular proliferation with more fibrosis than acute cases
  • Also primarily chronic inflammatory infiltrate, onion skin cuffing of fibroblasts around large bile ducts, variable cholestasis, variable Mallory hyaline in periportal hepatocytes
  • Usually no edema, minimal neutrophils, minimal interlobular bile ducts