Liver and intrahepatic bile ducts nontumor
General concepts
Biliary tract disease related


Topic Completed: 1 April 2012

Revised: 20 November 2019

Copyright: (c) 2003-2019, PathologyOutlines.com, Inc.

PubMed Search: Biliary tract disease [title] cirrhosis

Related topics: Cirrhosis

Komal Arora, M.D.
Page views in 2019: 420
Page views in 2020 to date: 107
Cite this page: Biliary tract disease related. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/livercirrhosisbiliarytract.html. Accessed February 21st, 2020.
Definition / general
  • Caused by primary biliary cirrhosis, primary or secondary sclerosing cholangitis, idiopathic inflammatory bowel disease, duct obstruction
Laboratory
  • Elevated serum alkaline phosphatase
Microscopic (histologic) description
  • Jigsaw pattern of cirrhosis due to portal to portal bridging fibrosis
  • No rounded cirrhotic nodules
  • Minimal distortion of central veins until late
  • May have cholangiole proliferation, portal tract inflammation with pericholangiole neutrophils, disruption of terminal plate by mononuclear cells and piecemeal necrosis
  • Often has prominent zone 1 cholate stasis (formerly referred to as "feathery degeneration") with deposition of copper associated protein and sometimes copper (orcein or Victoria blue)
Positive stains
  • Copper (due to chronic cholestasis)
Differential diagnosis
Back to top