Liver and intrahepatic bile ducts nontumor
General concepts
Biliary tract disease related

Topic Completed: 1 April 2012

Revised: 9 March 2020

Copyright: 2003-2020,, Inc.

PubMed Search: Biliary tract disease [title] cirrhosis

Related topics: Cirrhosis

Komal Arora, M.D.
Page views in 2019: 420
Page views in 2020 to date: 196
Cite this page: Biliary tract disease related. website. Accessed April 9th, 2020.
Definition / general
  • Caused by primary biliary cirrhosis, primary or secondary sclerosing cholangitis, idiopathic inflammatory bowel disease, duct obstruction
  • Elevated serum alkaline phosphatase
Microscopic (histologic) description
  • Jigsaw pattern of cirrhosis due to portal to portal bridging fibrosis
  • No rounded cirrhotic nodules
  • Minimal distortion of central veins until late
  • May have cholangiole proliferation, portal tract inflammation with pericholangiole neutrophils, disruption of terminal plate by mononuclear cells and piecemeal necrosis
  • Often has prominent zone 1 cholate stasis (formerly referred to as "feathery degeneration") with deposition of copper associated protein and sometimes copper (orcein or Victoria blue)
Positive stains
  • Copper (due to chronic cholestasis)
Differential diagnosis
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