Liver and intrahepatic bile ducts - nontumor
General concepts
Cirrhosis - features to report

Author: Anthony W.H. Chan, FRCPA (see Authors page)

Revised: 30 October 2017, last major update April 2017

Copyright: (c) 2002-2017, PathologyOutlines.com, Inc.

PubMed Search: Cirrhosis[TI] features to report

Table of Contents
Definition / general
Cite this page: Chan, A.W.H. Cirrhosis - features to report. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/livercirrhosisreport.html. Accessed November 24th, 2017.
Definition / general
  • Diagnosis: incomplete cirrhosis (Ishak stage 5) vs. probable / definite cirrhosis (Ishak stage 6) (J Hepatol 1995;22:696)
  • Subclassification: micronodular (< 3 mm) vs. macronodular (≥ 3 mm)
  • Subclassification: Laennec fibrosis scoring system (J Hepatol 2011;55:1004)
    • 4A: mild cirrhosis; marked septation with rounded contours or visible nodules; most septa are thin (one broad spectum allowed)
    • 4B: moderate cirrhosis with at least two broad septa
    • 4C: severe cirrhosis with at least one very broad septum or many minute nodules
    • Excellent interobserver agreement (kappa 0.83)
    • Correlate with severity of portal hypertension and Child-Pugh and MELD scores
  • Etiology
    • Clinical, biochemical and serological correlation is essential
    • Cryptogenic (idiopathic) cirrhosis accounts for 8 - 9% of liver transplants in the US; "burnt out" NAFLD / NASH is a common cause of cryptogenic cirrhosis (Hepatology 2000;32:689)