Liver and intrahepatic bile ducts - nontumor
General concepts
Cirrhosis - features to report

Author: Anthony W.H. Chan, FRCPA (see Authors page)

Revised: 1 May 2017, last major update April 2017

Copyright: (c) 2002-2017, PathologyOutlines.com, Inc.

PubMed Search: Cirrhosis [title] "features to report"

Table of Contents
Definition / general
Cite this page: Cirrhosis - features to report. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/livercirrhosisreport.html. Accessed September 24th, 2017.
Definition / general
  • Diagnosis: incomplete cirrhosis (Ishak’s stage 5) vs. probable / definite cirrhosis (Ishak’s stage 6) (J Hepatol 1995;22:696)
  • Subclassification - micronodular ( < 3 mm) vs. macronodular ( ≥ 3 mm)
  • Subclassification - Laennec fibrosis scoring system (J Hepatol 2011;55:1004)
    • 4A - Mild cirrhosis; marked septation with rounded contours or visible nodules; most septa are thin (one broad spectum allowed)
    • 4B - Moderate cirrhosis with at least two broad septa
    • 4C - Severe cirrhosis with at least one very broad septum or many minute nodules
    • Excellent interobserver agreement (kappa 0.83)
    • Correlate with severity of portal hypertension, and Child-Pugh and MELD scores
  • Etiology
    • Clinical, biochemical and serological correlation is essential
    • Cryptogenic (idiopathic) cirrhosis accounts for 8 - 9% of liver transplants in the US; "burnt-out" NAFLD / NASH is a common cause of cryptogenic cirrhosis (Hepatology 2000;32:689)