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Liver and intrahepatic bile ducts-nontumor

Jaundice

Conjugated hyperbilirubinemia


Reviewers: Komal Arora, M.D. (see Reviewers page)
Revised: 15 May 2012, last major update May 2012
Copyright: (c) 2004-2012, PathologyOutlines.com, Inc.

General
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● Due to decreased hepatic excretion or deficiency of canalicular membrane transporters (Dubin-Johnson syndrome, Rotor syndrome)
Dubin-Johnson syndrome: autosomal recessive, impaired excretion due to canalicular membrane-carrier defect, have darkly pigmented cytoplasmic globules in liver, asymptomatic; normal liver function tests; electron microscopy shows coarse granules in lysosomes which appear to be polymers of adrenaline metabolites
Rotor syndrome: rare, autosomal recessive, cause unknown, asymptomatic, liver is not pigmented

Micro images
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Brown-black pigment within hepatocytes

Additional references
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Best Pract Res Clin Gastroenterol 2010;24:555

End of Liver and intrahepatic bile ducts-nontumor > Jaundice > Conjugated hyperbilirubinemia


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