Cite this page: Arora K. Conjugated hyperbilirubinemia. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/liverconjugatedhyper.html. Accessed August 22nd, 2019.
Definition / general
- Due to decreased hepatic excretion or deficiency of canalicular membrane transporters (Dubin-Johnson syndrome, Rotor syndrome)
- Dubin-Johnson syndrome: autosomal recessive, impaired excretion due to canalicular membrane carrier defect, have darkly pigmented cytoplasmic globules in liver, asymptomatic; normal liver function tests; electron microscopy shows coarse granules in lysosomes which appear to be polymers of adrenaline metabolites
- Rotor syndrome: rare, autosomal recessive, cause unknown, asymptomatic, liver is not pigmented
Microscopic (histologic) images