Liver and intrahepatic bile ducts - nontumor
Jaundice
Conjugated hyperbilirubinemia



Topic Completed: 1 May 2012

Revised: 23 January 2019, last major update May 2012

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PubMed Search: Conjugated hyperbilirubinemia[TI]


Komal Arora, M.D.
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Cite this page: Arora K. Conjugated hyperbilirubinemia. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/liverconjugatedhyper.html. Accessed June 24th, 2019.
Definition / general
  • Due to decreased hepatic excretion or deficiency of canalicular membrane transporters (Dubin-Johnson syndrome, Rotor syndrome)
  • Dubin-Johnson syndrome: autosomal recessive, impaired excretion due to canalicular membrane carrier defect, have darkly pigmented cytoplasmic globules in liver, asymptomatic; normal liver function tests; electron microscopy shows coarse granules in lysosomes which appear to be polymers of adrenaline metabolites
  • Rotor syndrome: rare, autosomal recessive, cause unknown, asymptomatic, liver is not pigmented
Microscopic (histologic) images

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Brown black pigment within hepatocytes

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