Liver and intrahepatic bile ducts - nontumor
Conjugated hyperbilirubinemia

Author: Komal Arora, M.D. (see Authors page)

Revised: 9 November 2017, last major update May 2012

Copyright: (c) 2002-2017,, Inc.

PubMed Search: Conjugated hyperbilirubinemia[TI]

Cite this page: Arora, K. Conjugated hyperbilirubinemia. website. Accessed July 18th, 2018.
Definition / general
  • Due to decreased hepatic excretion or deficiency of canalicular membrane transporters (Dubin-Johnson syndrome, Rotor syndrome)
  • Dubin-Johnson syndrome: autosomal recessive, impaired excretion due to canalicular membrane carrier defect, have darkly pigmented cytoplasmic globules in liver, asymptomatic; normal liver function tests; electron microscopy shows coarse granules in lysosomes which appear to be polymers of adrenaline metabolites
  • Rotor syndrome: rare, autosomal recessive, cause unknown, asymptomatic, liver is not pigmented
Microscopic (histologic) images

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Brown black pigment within hepatocytes