Liver and intrahepatic bile ducts - nontumor
Developmental anomalies / cysts
Down syndrome

Author: Komal Arora, M.D. (see Authors page)

Revised: 25 October 2017, last major update April 2012

Copyright: (c) 2002-2017,, Inc.

PubMed Search: Down syndrome[TI] liver

Cite this page: Arora, K. Down syndrome. website. Accessed October 24th, 2018.
Definition / general
  • Increased liver volume at gestational weeks 11 and 13 (Prenat Diagn 2011;31:28)
  • Hepatic dysfunction in infant with trisomy 21 is likely due to transient myeloproliferative disorder with hepatic infiltration by hematopoietic elements, associated with secondary hemosiderosis
Case reports
  • Associated with liver fibrosis, thought to be due to megakaryocyte derived transforming growth factor beta (Hum Pathol 1999;30:474)
Microscopic (histologic) images

Images hosted on other servers:

Liver failure with portopulmonary hypertension secondary to neonatal hemochromatosis