Liver and intrahepatic bile ducts - nontumor
Developmental anomalies / cysts
Down syndrome

Topic Completed: 1 April 2012

Revised: 22 January 2019, last major update April 2012

Copyright: (c) 2002-2017,, Inc.

PubMed Search: Down syndrome[TI] liver

Komal Arora, M.D.
Page views in 2018: 82
Page views in 2019 to date: 109
Cite this page: Arora K. Down syndrome. website. Accessed September 22nd, 2019.
Definition / general
  • Increased liver volume at gestational weeks 11 and 13 (Prenat Diagn 2011;31:28)
  • Hepatic dysfunction in infant with trisomy 21 is likely due to transient myeloproliferative disorder with hepatic infiltration by hematopoietic elements, associated with secondary hemosiderosis
Case reports
  • Associated with liver fibrosis, thought to be due to megakaryocyte derived transforming growth factor beta (Hum Pathol 1999;30:474)
Microscopic (histologic) images

Images hosted on other servers:

Liver failure with portopulmonary hypertension secondary to neonatal hemochromatosis

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