Liver and intrahepatic bile ducts - nontumor
Developmental anomalies / cysts
Down syndrome

Author: Komal Arora, M.D. (see Authors page)

Revised: 25 October 2017, last major update April 2012

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PubMed Search: Down syndrome[TI] liver

Cite this page: Arora, K. Down syndrome. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/liverdowns.html. Accessed December 12th, 2017.
Definition / general
  • Increased liver volume at gestational weeks 11 and 13 (Prenat Diagn 2011;31:28)
  • Hepatic dysfunction in infant with trisomy 21 is likely due to transient myeloproliferative disorder with hepatic infiltration by hematopoietic elements, associated with secondary hemosiderosis
Case reports
  • Associated with liver fibrosis, thought to be due to megakaryocyte derived transforming growth factor beta (Hum Pathol 1999;30:474)
Microscopic (histologic) images

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Liver failure with portopulmonary hypertension secondary to neonatal hemochromatosis