Cite this page: Arora K. Down syndrome. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/liverdowns.html. Accessed September 22nd, 2019.
Definition / general
- Increased liver volume at gestational weeks 11 and 13 (Prenat Diagn 2011;31:28)
- Hepatic dysfunction in infant with trisomy 21 is likely due to transient myeloproliferative disorder with hepatic infiltration by hematopoietic elements, associated with secondary hemosiderosis
- Associated with liver fibrosis, thought to be due to megakaryocyte derived transforming growth factor beta (Hum Pathol 1999;30:474)