Liver and intrahepatic bile ducts - nontumor
Infectious (nonviral) disorders
Fasciola hepatica (liver fluke)

Author: Komal Arora, M.D. (see Authors page)

Revised: 2 November 2017, last major update May 2012

Copyright: (c) 2002-2017, PathologyOutlines.com, Inc.

PubMed Search: Fasciola hepatica[TI] liver fluke[TI] full text[sb]

Cite this page: Arora, K. Fasciola hepatica (liver fluke). PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/liverfasciolahepatica.html. Accessed December 12th, 2017.
Definition / general
  • Common liver fluke or sheep liver fluke; parasitic flatworm of class Trematoda, phylum Platyhelminthes; infects livers of various mammals, including humans (Wikipedia: Fasciola hepatica [Accessed 2 November 2017])
  • Occurs in Southeast Asia and other locations where population consumes watercress or other freshwater plants containing metacercariae (Gastroenterol Clin North Am 1996;25:627)
  • Usually produces lesions in liver, rarely gallbladder and stomach
  • Parasite penetrates hepatic capsule, migrates into bile ducts causing necrosis, scarring and eosinophilic granulomas
  • Diagnosis: operculated eggs in stool, duodenal or biliary drainage; immunodiagnostic testing
Diagrams / tables

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Life cycle

Case reports
Clinical images

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Eggs

Adult worms

Gross description
  • Solitary or multiple surface yellow nodules, 5 - 20 mm, resembling metastases
  • Cut sections show tracks ending at subcapsular cavities filled with necrotic material
Microscopic (histologic) description
  • Dilated intrahepatic bile ducts contain adult flukes, necrotic debris, eosinophils with Charcot-Leyden crystals, histiocytes, eosinophilic granulomas
  • Also dystrophic calcification
  • Rarely eggs
Microscopic (histologic) images

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65 year old woman

Various images

Videos

Dr. Schall's parasitology reviews