Liver and intrahepatic bile ducts-nontumor
Infectious (non-viral) disorders
Fasciola hepatica (liver fluke)
Reviewers: Komal Arora, M.D. (see Reviewers page)
Revised: 8 June 2012, last major update May 2012
Copyright: (c) 2004-2012, PathologyOutlines.com, Inc.
● Common liver fluke or sheep liver fluke; parasitic flatworm of class Trematoda, phylum Platyhelminthes; infects livers of various mammals, including humans (Wikipedia)
● Occurs in Southeast Asia and other locations where population consumes watercress or other freshwater plants containing metacercariae (Gastroenterol Clin North Am 1996;25:627)
● Usually produces lesions in liver, rarely gallbladder and stomach
● Parasite penetrates hepatic capsule, migrates into bile ducts causing necrosis, scarring and eosinophilic granulomas
● Diagnosis: operculated eggs in stool, duodenal or biliary drainage; immunodiagnostic testing
● Solitary or multiple surface yellow nodules, 5-20 mm, resembling metastases
● Cut sections show tracks ending at subcapsular cavities filled with necrotic material
● 65 year old woman with right upper quadrant discomfort (J Radiol Case Rep 2010;4:13)
● Dilated intrahepatic bile ducts contain adult flukes, necrotic debris, eosinophils with Charcot-Leyden crystals, histiocytes, eosinophilic granulomas
● Also dystrophic calcification
● Rarely eggs
65 year old woman
Dr. Schall's Parasitology Reviews
End of Liver and intrahepatic bile ducts-nontumor > Infectious (non-viral) disorders > Fasciola hepatica (liver fluke)
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