Liver and intrahepatic bile ducts - nontumor
Metabolic diseases
Hereditary fructose intolerance

Topic Completed: 1 April 2012

Revised: 24 February 2020

Copyright: 2002-2020,, Inc.

PubMed Search: Hereditary fructose intolerance[TI] liver

Komal Arora, M.D.
Page views in 2019: 126
Page views in 2020 to date: 33
Cite this page: Arora K. Hereditary fructose intolerance. website. Accessed April 6th, 2020.
Definition / general
Diagrams / tables

Images hosted on other servers:

Fructose metabolism

Microscopic (histologic) description
  • Hepatocellular degeneration with focal fatty change, particularly in regenerative nodules; pseudorosettes, cholestasis, fibrosis, cirrhosis
Microscopic (histologic) images

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Macrovesicular fatty changes with periportal and perivenular fibrosis, suggestive of metabolic liver disease

Electron microscopy description
  • Lucent partially membrane bound areas of cytoplasm ("fructose holes"), concentric arrays of endoplasmic reticulum and glycogen
Electron microscopy images

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Microvesicular fat
droplets in hepatocyte,
focal cytoplasmic

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