Liver and intrahepatic bile ducts - nontumor
Metabolic diseases
Hereditary fructose intolerance

Author: Komal Arora, M.D. (see Authors page)

Revised: 14 November 2017, last major update April 2012

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PubMed Search: Hereditary fructose intolerance[TI] liver

Cite this page: Arora, K. Hereditary fructose intolerance. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/liverfructoseintol.html. Accessed December 16th, 2017.
Definition / general
Diagrams / tables

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Fructose metabolism

Microscopic (histologic) description
  • Hepatocellular degeneration with focal fatty change, particularly in regenerative nodules; pseudorosettes, cholestasis, fibrosis, cirrhosis
Microscopic (histologic) images

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Macrovesicular fatty changes with periportal and perivenular fibrosis, suggestive of metabolic liver disease

Electron microscopy description
  • Lucent partially membrane bound areas of cytoplasm ("fructose holes"), concentric arrays of endoplasmic reticulum and glycogen
Electron microscopy images

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Microvesicular fat
droplets in hepatocyte,
focal cytoplasmic
necrosis