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Liver and intrahepatic bile ducts-nontumor
Viral hepatitis
Hepatitis E virus
Reviewers: Komal Arora, M.D. (see Reviewers page)
Revised: 12 May 2012, last major update May 2012
Copyright: (c) 2004-2012, PathologyOutlines.com, Inc.
General
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● Rare in United States; initial outbreak in 1978 in Kashmir Valley with 52,000 cases and 1500 deaths
● Fecal-oral transmission similar to Hepatitis A, often through contaminated water
● Associated with poor outcome in pregnant women (up to 22% fatality rate due to disseminated intravascular coagulation and fulminant hepatitis)
● May cause acute cholestatic hepatitis with bile ductular proliferation, neutrophils around ducts, cholestasis, hepatocyte ballooning, pseudo-glands around bile plugs
Virology
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● Due to Calicivirus
Drawing of virion
Micro description
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● Resembles Hepatitis A with canalicular cholestasis, dense portal and periportal inflammation
Additional references
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End of Liver and intrahepatic bile ducts-nontumor > Viral hepatitis > Hepatitis E virus
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