Liver and intrahepatic bile ducts - nontumor
Viral hepatitis
Hepatitis E virus

Topic Completed: 1 May 2012

Revised: 23 January 2019, last major update May 2012

Copyright: (c) 2002-2017,, Inc.

PubMed Search: Hepatitis E virus[TI] liver[TI]

Komal Arora, M.D.
Page views in 2019: 386
Page views in 2020 to date: 105
Cite this page: Arora K. Hepatitis E virus. website. Accessed April 9th, 2020.
Definition / general
  • Rare in United States; initial outbreak in 1978 in Kashmir Valley with 52,000 cases and 1,500 deaths
  • Fecal - oral transmission similar to hepatitis A, often through contaminated water
  • Associated with poor outcome in pregnant women (up to 22% fatality rate due to disseminated intravascular coagulation and fulminant hepatitis)
  • May cause acute cholestatic hepatitis with bile ductular proliferation, neutrophils around ducts, cholestasis, hepatocyte ballooning, pseudoglands around bile plugs
  • Due to calicivirus
Diagrams / tables

Images hosted on other servers:

Drawing of virion

Microscopic (histologic) description
  • Resembles hepatitis A with canalicular cholestasis, dense portal and periportal inflammation
Additional references
Back to top