Liver and intrahepatic bile ducts - nontumor
Viral hepatitis
Hepatitis E virus

Author: Komal Arora, M.D. (see Authors page)

Revised: 6 November 2017, last major update May 2012

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PubMed Search: Hepatitis E virus[TI] liver[TI]

Cite this page: Arora, K. Hepatitis E virus. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/liverhepE.html. Accessed November 24th, 2017.
Definition / general
  • Rare in United States; initial outbreak in 1978 in Kashmir Valley with 52,000 cases and 1,500 deaths
  • Fecal - oral transmission similar to hepatitis A, often through contaminated water
  • Associated with poor outcome in pregnant women (up to 22% fatality rate due to disseminated intravascular coagulation and fulminant hepatitis)
  • May cause acute cholestatic hepatitis with bile ductular proliferation, neutrophils around ducts, cholestasis, hepatocyte ballooning, pseudoglands around bile plugs
Virology
  • Due to calicivirus
Diagrams / tables

Images hosted on other servers:

Drawing of virion

Microscopic (histologic) description
  • Resembles hepatitis A with canalicular cholestasis, dense portal and periportal inflammation
Additional references