Liver and intrahepatic bile ducts-nontumor - Hepatitis

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Liver and intrahepatic bile ducts-nontumor

Hepatitis - general

Reviewers: Komal Arora, M.D. (see Reviewers page)
Revised: 30 April 2012, last major update April 2012
Copyright: (c) 2004-2012, PathologyOutlines.com, Inc.

General
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● Hepatocyte injury plus acute or chronic inflammatory cells
● T cells commonly attack viable hepatocytes
● Scavenger macrophages engulf dead hepatocytes within hours
● Granulomatous reaction due to foreign bodies, organisms, drugs
● Regeneration occurs in all but most fulminant diseases; see mitotic activity, thickening of hepatocyte cords, disorganization of parenchymal structure
● Prominent bile duct profiles within portal tracts suggests bile duct epithelial proliferation

Differential diagnosis
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● Early biliary disease: normal periportal hepatocytes with no necrosis, no swelling, no rosette formation; mononuclear cells don’t encircle hepatocytes, fibrosis doesn’t form leaf-like extensions into nodule; positive for antimitochondrial antibody, other antibodies

End of Liver and intrahepatic bile ducts-nontumor > Hepatitis - general

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