Home   Chapter Home   Jobs   Conferences   Fellowships   Books



Advertisement

Liver and intrahepatic bile ducts-nontumor

Developmental anomalies/cysts

Intrahepatic biliary atresia


Reviewers: Komal Arora, M.D. (see Reviewers page)
Revised: 23 April 2012, last major update April 2012
Copyright: (c) 2004-2012, PathologyOutlines.com, Inc.

General
=========================================================================

● Also called paucity of intrahepatic bile ducts in neonates
● Occurs in syndromic form (Alagille’s syndrome) or nonsyndromic form (Eur J Hum Genet. 2012 Mar;20(3):251-7)
● In nonsyndromic form, bile duct loss is present from birth
● May actually represent cystic fibrosis, alpha-1-antitrypsin deficiency, trihydroxycoprostanic acidemia
● Bile duct recovery depends on etiology

Micro description
=========================================================================

● Loss of interlobular bile ducts (0.5 ducts/portal tract vs. normal 0.9-1.8 ducts/portal tract
● Count only bile ducts accompanying hepatic arterioles in center of portal tracts, keratin staining may be helpful)
● Usually minimal ductular proliferation
● No/minimal fibrosis, no/minimal inflammation

Micro images
=========================================================================



Various images

   
Alagille syndrome with bile duct paucity

End of Liver and intrahepatic bile ducts-nontumor > Developmental anomalies/cysts > Intrahepatic biliary atresia


This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.

All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com with any questions (click here for other contact information).