Home   Chapter Home   Jobs   Conferences   Fellowships   Books



Advertisement

Liver and intrahepatic bile ducts-nontumor

Jaundice

Physiology


Reviewers: Komal Arora, M.D. (see Reviewers page)
Revised: 15 May 2012, last major update May 2012
Copyright: (c) 2004-2012, PathologyOutlines.com, Inc.

General
=========================================================================

● Total bilirubin > 2.0 mg/dl (normal is 0.3 to 1.2 mg/dl)
● Conjugated bilirubin (produced by normal liver) is water soluble, nontoxic, loosely bound to albumin; can be excreted in urine
● Unconjugated bilirubin and bilirubin glucuronides are insoluble in water and tightly complexed to albumin; cannot be excreted in urine despite high levels due to insolubility; may diffuse into tissues and produce toxic brain injury
● Hemolytic disease of newborn (erythroblastosis fetalis) causes severe neurologic damage (kernicterus) due to accumulation of unconjugated bilirubin

Causes
=========================================================================

● Excessive production of bilirubin that overwhelms liverís conjugating capacity, reduced hepatocyte uptake of bilirubin, other causes of impaired conjugation, decreased hepatocyte excretion of bilirubin, impaired bile flow (intra- or extrahepatic)

End of Liver and intrahepatic bile ducts-nontumor > Jaundice > Physiology


This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.

All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com with any questions (click here for other contact information).