Liver and intrahepatic bile ducts-nontumor
Reviewers: Komal Arora, M.D. (see Reviewers page)
Revised: 15 May 2012, last major update May 2012
Copyright: (c) 2004-2012, PathologyOutlines.com, Inc.
● Total bilirubin > 2.0 mg/dl (normal is 0.3 to 1.2 mg/dl)
● Conjugated bilirubin (produced by normal liver) is water soluble, nontoxic, loosely bound to albumin; can be excreted in urine
● Unconjugated bilirubin and bilirubin glucuronides are insoluble in water and tightly complexed to albumin; cannot be excreted in urine despite high levels due to insolubility; may diffuse into tissues and produce toxic brain injury
● Hemolytic disease of newborn (erythroblastosis fetalis) causes severe neurologic damage (kernicterus) due to accumulation of unconjugated bilirubin
● Excessive production of bilirubin that overwhelms liverís conjugating capacity, reduced hepatocyte uptake of bilirubin, other causes of impaired conjugation, decreased hepatocyte excretion of bilirubin, impaired bile flow (intra- or extrahepatic)
End of Liver and intrahepatic bile ducts-nontumor > Jaundice > Physiology
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