Liver and intrahepatic bile ducts - nontumor
Infectious (nonviral) disorders

Topic Completed: 1 May 2012

Revised: 23 January 2019, last major update May 2012

Copyright: (c) 2002-2017,, Inc.

PubMed Search: Malakoplakia liver

Komal Arora, M.D.
Page views in 2019: 58
Page views in 2020 to date: 16
Cite this page: Arora K. Malakoplakia. website. Accessed March 31st, 2020.
Definition / general
  • Rare in liver; more common in bladder but described in numerous locations
  • Usually associated with Klebsiella and Escherichia coli infection but also other bacteria, often in association with underlying systemic disease
  • Three phases:
    1. Histiocytes (also called von Hansemann histiocytes after codiscoverer) and plasma cells early
    2. Granulomatous phase with numerous Michaelis-Gutmann calcospherites
    3. Late fibroblasts and collagen with histiocytes and only rare Michaelis-Gutmann bodies
  • Apparently due to defective macrophages that phagocytose bacteria but cannot digest them, causing enlarged phagolysosomes which accumulate crystals, leading to laminated Michaelis-Gutmann inclusions
Case reports
Microscopic (histologic) description
  • Aggregates of histiocytes containing small, round to oval, targetoid structures (Michaelis-Gutmann bodies)
Microscopic (histologic) images

Images hosted on other servers:

H&E and stains, EM

Positive stains
Additional references
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