Liver and intrahepatic bile ducts-nontumor

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Liver and intrahepatic bile ducts-nontumor

Infectious (non-viral) disorders

Mycobacteria

Reviewers: Komal Arora, M.D. (see Reviewers page)
Revised: 12 May 2012, last major update May 2012
Copyright: (c) 2004-2012, PathologyOutlines.com, Inc.

General
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● Granulomas usually lobular, organisms identified with acid-fast stain

Atypical mycobacteria

General
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● Includes mycobacterium avium-intracellulare complex
● Non-caseating granulomas

Case reports
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● 55 year old HIV+ man with enlarged and granular liver by ultrasound (Case of the Week #223)

Micro images
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Non-caseating granuloma of M. avium intracellulare; right-with acid-fast stain

M. leprae

General
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● Liver granulomas present in lepromatous leprosy
● May cause relapse

Micro description
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● Large histiocytes (“lepra cells”) with clear cytoplasm containing weakly acid-fast bacilli

Micro images
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Large histiocytes with clear cytoplasm; right-with Fite acid-fast stain

M. mucogenicum

General
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● Member of M. fortuitum-chelonae complex; formerly classified as M. chelonae-like
● Water contaminant in hospitals
● Rapid-growing, rarely present in human infections
● Culture: smooth, nonpigmented, tan-white, undulating edges, rapid-growing colonies

Case reports
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● 51 year old man with rapidly progressive granulomatous hepatitis (Arch Pathol Lab Med 2002;126:73)

Images
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Liver - gross, granulomatous inflammation and necrosis, gross culture morphology

M. tuberculosis

General
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● Caseating granulomas

Micro images
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Early non-caseating granuloma

End of Liver and intrahepatic bile ducts-nontumor > Infectious (non-viral) disorders > Mycobacteria

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