Liver and intrahepatic bile ducts - nontumor
Infectious (nonviral) disorders
Penicillium marneffei

Topic Completed: 1 May 2012

Revised: 23 January 2019, last major update May 2012

Copyright: (c) 2002-2017,, Inc.

PubMed Search: Penicillium marneffei liver

Komal Arora, M.D.
Page views in 2019: 144
Page views in 2020 to date: 72
Cite this page: Arora K. Penicillium marneffei. website. Accessed March 28th, 2020.
Definition / general
  • Opportunistic fungus, endemic in Southeast Asia, particularly HIV+ patients in northern Thailand
  • Causes deep seated infections, focal or disseminated, with fever, generalized lymphadenopathy, hepatosplenomegaly, mucosal ulcers, skin lesions
  • Granulomatous response may reflect more intact cell mediated immune function (Arch Pathol Lab Med 2004;128:191)
  • Diagnosis: liver biopsy
Microscopic (histologic) description
  • Hepatic lesions either diffuse, granulomatous or mixed
  • Diffuse pattern contains widespread macrophages containing fungi but minimal other inflammatory cells
  • Granulomatous pattern contains multiple granulomas
  • Within macrophages, fungi is round oval, yeast-like, measuring 2 - 7 microns, with central septum and no budding forms
  • Outside of cells, it is up to 15 microns long
Microscopic (histologic) images

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