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Liver and intrahepatic bile ducts-nontumor

Infectious (non-viral) disorders

Penicillium marneffei


Reviewers: Komal Arora, M.D. (see Reviewers page)
Revised: 27 June 2012, last major update May 2012
Copyright: (c) 2004-2012, PathologyOutlines.com, Inc.

General
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● Opportunistic fungus, endemic in Southeast Asia, particularly HIV+ patients in northern Thailand
● Causes deep-seated infections, focal or disseminated, with fever, generalized lymphadenopathy, hepatosplenomegaly, mucosal ulcers, skin lesions
● Granulomatous response may reflect more intact cell mediated immune function (Arch Pathol Lab Med 2004;128:191)
Diagnosis: liver biopsy

Micro description
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● Hepatic lesions either diffuse, granulomatous or mixed
● Diffuse pattern contains widespread macrophages containing fungi, but minimal other inflammatory cells
● Granulomatous pattern contains multiple granulomas
● Within macrophages, fungi is round-oval, yeastlike, measuring 2-7 microns, with central septum and no budding forms
● Outside of cells, it is up to 15 microns long

Micro images
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GMS, H&E, PAS

End of Liver and intrahepatic bile ducts-nontumor > Infectious (non-viral) disorders > Penicillium marneffei


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