Liver and intrahepatic bile ducts - nontumor
Infectious (nonviral) disorders
Penicillium marneffei



Topic Completed: 1 May 2012

Revised: 23 January 2019, last major update May 2012

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PubMed Search: Penicillium marneffei liver


Komal Arora, M.D.
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Cite this page: Arora K. Penicillium marneffei. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/liverpenicillium.html. Accessed August 24th, 2019.
Definition / general
  • Opportunistic fungus, endemic in Southeast Asia, particularly HIV+ patients in northern Thailand
  • Causes deep seated infections, focal or disseminated, with fever, generalized lymphadenopathy, hepatosplenomegaly, mucosal ulcers, skin lesions
  • Granulomatous response may reflect more intact cell mediated immune function (Arch Pathol Lab Med 2004;128:191)
  • Diagnosis: liver biopsy
Microscopic (histologic) description
  • Hepatic lesions either diffuse, granulomatous or mixed
  • Diffuse pattern contains widespread macrophages containing fungi but minimal other inflammatory cells
  • Granulomatous pattern contains multiple granulomas
  • Within macrophages, fungi is round oval, yeast-like, measuring 2 - 7 microns, with central septum and no budding forms
  • Outside of cells, it is up to 15 microns long
Microscopic (histologic) images

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GMS, H&E, PAS

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