Liver and intrahepatic bile ducts - nontumor
Vascular disorders
Portal hypertension



Topic Completed: 1 January 2018

Revised: 24 January 2019, last major update January 2018

Copyright: (c) 2003-2018, PathologyOutlines.com, Inc.

PubMed Search: Portal hypertension[TI] liver[TI] free full text[sb]pathology


Raul S. Gonzalez, M.D.
Page views in 2018: 871
Page views in 2019 to date: 1,037
Cite this page: Gonzalez R. Portal hypertension. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/liverportalhypertension.html. Accessed December 13th, 2019.
Definition / general
  • Increased blood pressure within portal venous system
Essential features
  • Causes are numerous and can be divided into prehepatic, intrahepatic and post hepatic
  • Cirrhosis is most common cause
Terminology
  • Patients without cirrhosis typically are labeled with "noncirrhotic portal hypertension"
Etiology
Clinical features
  • Clinical complications include ascites, portosystemic venous shunts (hemorrhoidal veins, esophageal varices, etc.), congestive splenomegaly, hepatic encephalopathy
Diagnosis
  • Gold standard is measurement of hepatic venous pressure gradient via portal vein catheterization
  • Ultrasound is noninvasive and can detect signs of portal hypertension
Microscopic (histologic) description
Microscopic (histologic) images

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Idiopathic non-cirrhotic portal hypertension

Board review question #1
    A patient is found to have portal hypertension in the absence of cirrhosis. Considering the most common overall cause of noncirrhotic portal hypertension, which of the following is most likely to be seen on liver biopsy?

  1. Herniated portal veins
  2. Mastocytosis
  3. Nodular hepatocyte parenchyma
  4. Parasite eggs
  5. Sinusoidal fibrosis
Board review answer #1
D. Parasite eggs: Schistosomiasis is the most common cause of noncirrhotic portal hypertension in the world
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