Liver and intrahepatic bile ducts-nontumor - Post-bone marrow transplantation

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Liver and intrahepatic bile ducts-nontumor

Transplantation

Post-bone marrow transplantation

Reviewers: Komal Arora, M.D. (see Reviewers page)
Revised: 23 May 2012, last major update May 2012
Copyright: (c) 2004-2012, PathologyOutlines.com, Inc.

Clinical features
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● Shortly after donor marrow administration: weight gain, tenderness, edema, ascites
● Within first 30 days: fungal and CMV infection, veno-occlusive disease or nodular regenerative hyperplasia
● Delayed complication: focal nodular hyperplasia is frequent at median 6 years post-transplant in children (Bone Marrow Transplant 2009;43:127)
● Poor outcome likely if severe liver toxicity or severe liver dysfunction
● Frequent iron overload contributes to liver dysfunction (Bone Marrow Transplant 2008;42:461, Eur J Gastroenterol Hepatol 2004;16:157)
● Death due to septicemia, pneumonia, bleeding, multiorgan failure

Laboratory
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● Elevated serum bilirubin, fall in urinary sodium excretion (Clin Transplant 2011;25:E552)

Micro description
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● Centrilobular necrosis, veno-occlusive disease
● Sinusoidal obstruction syndrome (Blood 2009;114:1270, Curr Gastroenterol Rep.2007;9:60, Leuk Lymphoma 2012 Mar 13 [Epub ahead of print])

End of Liver and intrahepatic bile ducts-nontumor > Transplantation > Post-bone marrow transplantation

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