Liver and intrahepatic bile ducts - nontumor
Post bone marrow transplantation

Topic Completed: 1 May 2012

Revised: 24 January 2019, last major update May 2012

Copyright: (c) 2002-2017,, Inc.

PubMed Search: Bone marrow transplantation[TI] liver[TI] full text[sb]

Komal Arora, M.D.
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Cite this page: Arora K. Post bone marrow transplantation. website. Accessed March 31st, 2020.
Clinical features
  • Shortly after donor marrow administration: weight gain, tenderness, edema, ascites
  • Within first 30 days: fungal and CMV infection, veno-occlusive disease or nodular regenerative hyperplasia
  • Delayed complication: focal nodular hyperplasia is frequent at median 6 years posttransplant in children (Bone Marrow Transplant 2009;43:127)
  • Poor outcome likely if severe liver toxicity or severe liver dysfunction
  • Frequent iron overload contributes to liver dysfunction (Bone Marrow Transplant 2008;42:461, Eur J Gastroenterol Hepatol 2004;16:157)
  • Death due to septicemia, pneumonia, bleeding, multiorgan failure
Microscopic (histologic) description
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