Liver and intrahepatic bile ducts - nontumor
Hepatitis (acute and chronic)
Prolonged resolving acute hepatitis



Topic Completed: 1 March 2015

Revised: 23 January 2019, last major update March 2015

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PubMed Search: Prolonged resolving acute hepatitis


Rifat Mannan, M.D.
Page views in 2018: 231
Page views in 2019 to date: 167
Cite this page: Mannan A.A.S.R. Prolonged resolving acute hepatitis. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/liverprolongedresolving.html. Accessed June 26th, 2019.
Definition / general
  • Acute hepatitis: hepatic inflammation that lasts less than six months
  • Associated with disease ranging from subclinical to self limited symptomatic to fulminant hepatic failure
  • Usually is self limited with recovery within 1 - 2 months from onset of symptoms but in "prolonged resolving" cases, lasts > 6 months and regresses slowly thereafter
Microscopic (histologic) description
  • Necrosis subsides and phagocytic activity predominates during regression
  • Mild portal inflammation is present and clumps of Kupffer cells are often seen
  • Ductular reaction is seen in severe cases
  • Cholestasis may persist after inflammation and necrosis have subsided
  • There are no dense bundles of collagen and elastic fibers
Microscopic (histologic) images

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Resolving hepatitis

Differential diagnosis
  • Chronic hepatitis
    • Portal inflammation is prominent
    • Dense bundles of collagen and elastic fibers are present
    • Phagocytic activity and clumps of Kupffer cells are usually NOT seen
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