Liver and intrahepatic bile ducts-nontumor

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Liver and intrahepatic bile ducts-nontumor

Transplantation

Pseudopeliotic steatosis

Reviewers: Komal Arora, M.D. (see Reviewers page)
Revised: 27 May 2012, last major update May 2012
Copyright: (c) 2004-2012, PathologyOutlines.com, Inc.

General
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● Formerly called lipopeliosis
● Pathophysiology: steatotic hepatocytes are present in donor liver
● Preservation injury causes their death with loss of fat
● Fat droplets accumulate to form fat globules that mimic dilated sinusoids (week 1), then are surrounded by macrophages and cleared by 3-4 weeks

Micro description
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● Apparent sinusoidal engorgement by large fat globules, although fat globules are actually outside sinusoids when collagen IV immunostaining is performed
● Variably damaged hepatocytes

Additional references
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● Am J Surg Pathol 2002;26:134, J Clin Pathol 1992;45:1109

End of Liver and intrahepatic bile ducts-nontumor > Transplantation > Pseudopeliotic steatosis

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