Liver and intrahepatic bile ducts-nontumor
Infectious (non-viral) disorders
Reviewers: Komal Arora, M.D. (see Reviewers page)
Revised: 12 May 2012, last major update May 2012
Copyright: (c) 2004-2012, PathologyOutlines.com, Inc.
● First described in 1963 by Reye and colleagues
● Encephalopathy and fatty degeneration of liver in children due to mitochondrial dysfunction after febrile viral-like illness treated with aspirin
● Disease has almost disappeared in children as aspirin use has declined for viral-like illnesses
● Current cases are more common in adults; in children are associated with inborn errors of urea cycle or fatty acid metabolism
● Changes similar to Jamaican vomiting sickness and valproic acid toxicity
● Diffuse, panlobular, microvesicular fatty change, no necrosis, no inflammation
● Fat stains
Electron macroscopy description
● Enlarged, pleomorphic mitochondria with expanded matrix and fewer mitochondrial dense bodies
● Cell Biochem Funct 2008;26:741
End of Liver and intrahepatic bile ducts-nontumor > Infectious (non-viral) disorders > Reye’s syndrome
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