Liver and intrahepatic bile ducts-nontumor

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Liver and intrahepatic bile ducts-nontumor

Infectious (non-viral) disorders

Reye’s syndrome

Reviewers: Komal Arora, M.D. (see Reviewers page)
Revised: 12 May 2012, last major update May 2012
Copyright: (c) 2004-2012, PathologyOutlines.com, Inc.

General
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● First described in 1963 by Reye and colleagues
● Encephalopathy and fatty degeneration of liver in children due to mitochondrial dysfunction after febrile viral-like illness treated with aspirin
● Disease has almost disappeared in children as aspirin use has declined for viral-like illnesses
● Current cases are more common in adults; in children are associated with inborn errors of urea cycle or fatty acid metabolism
● Changes similar to Jamaican vomiting sickness and valproic acid toxicity

Micro description
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● Diffuse, panlobular, microvesicular fatty change, no necrosis, no inflammation

Positive stains
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● Fat stains

Electron macroscopy description
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● Enlarged, pleomorphic mitochondria with expanded matrix and fewer mitochondrial dense bodies

Additional references
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● Cell Biochem Funct 2008;26:741

End of Liver and intrahepatic bile ducts-nontumor > Infectious (non-viral) disorders > Reye’s syndrome

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