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Liver and intrahepatic bile ducts-nontumor

Systemic disease/conditions

Sarcoidosis


Reviewers: Komal Arora, M.D. (see Reviewers page)
Revised: 16 May 2012, last major update May 2012
Copyright: (c) 2004-2012, PathologyOutlines.com, Inc.

General
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● Need clinical information to confirm diagnosis
● 60-90% have hepatic granulomas, but usually subclinical
● Occasionally associated with chronic intrahepatic cholestasis, portal hypertension, Budd-Chiari syndrome
● Case report of selective involvement of second liver allograft (Mod Pathol 1999;12:325)

Micro description
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● Granulomatous hepatitis with portal and lobular granulomas; granulomas are not duct-centered
● Granulomas may coalesce leading to scarring
● Hepatic fibrosis in 21%, cirrhosis in 6%
● Usually minimal other inflammatory cells

End of Liver and intrahepatic bile ducts-nontumor > Systemic disease/conditions > Sarcoidosis


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