Liver and intrahepatic bile ducts - nontumor
Systemic diseases / conditions

Topic Completed: 1 May 2012

Revised: 23 January 2019, last major update May 2012

Copyright: (c) 2002-2017,, Inc.

PubMed Search: Sarcoidosis[TI] liver[TI] full text[sb]

Komal Arora, M.D.
Page views in 2018: 373
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Cite this page: Arora K. Sarcoidosis. website. Accessed September 18th, 2019.
Definition / general
  • Need clinical information to confirm diagnosis
  • 60 - 90% have hepatic granulomas but usually subclinical
  • Occasionally associated with chronic intrahepatic cholestasis, portal hypertension, Budd-Chiari syndrome
Case reports
Microscopic (histologic) description
  • Granulomatous hepatitis with portal and lobular granulomas; granulomas are not duct centered
  • Granulomas may coalesce leading to scarring
  • Hepatic fibrosis in 21%, cirrhosis in 6%
  • Usually minimal other inflammatory cells
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