Liver and intrahepatic bile ducts - tumor
Benign tumors / conditions
Extramedullary hematopoiesis

Author: Shilpa Jain, M.D. (see Authors page)

Revised: 28 August 2018, last major update August 2012

Copyright: (c) 2002-2018,, Inc.

PubMed Search: Extramedullary hematopoiesis[TI] liver

Cite this page: Jain, S. Extramedullary hematopoiesis. website. Accessed October 16th, 2018.
Definition / general
  • Usually discovered incidentally or associated with anemia
  • Rarely presents as liver mass
  • Only very few liver nodules of EMH have been described in the literature (Diagn Cytopathol 1997;16:51)
Case reports
  • Radiation or hydroxyurea if symptomatic
Microscopic (histologic) description
  • Erythroid precursors in sinusoids (resemble lymphocytes), myeloid precursors in portal tracts (resemble mixed portal infiltrate or eosinophils in neonates)
  • Also megakaryocytes within sinuses
Microscopic (histologic) images

Images hosted on PathOut server:

Images contributed by Dr. S. Rajendiran, Sri Ramachandra University (India):

50 year old man with vague abdominal pain; CT abdomen showed a 2 cm mass; CT guided biopsy performed

Images hosted on other servers:

H&E and CD68

Images contributed by Dr. Nikhil Sangle, University of Utah Health Sciences Center and ARUP Laboratories:

Liver with extramedullary hematopoiesis

Cytology images

Images hosted on other servers:

Diff-Quik (2), Pap stain

Differential diagnosis