Liver and intrahepatic bile ducts - Tumor - Extramedullary hematopoiesis

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Liver and intrahepatic bile ducts - Tumor

Benign tumors

Extramedullary hematopoiesis

Reviewers: Deepali Jain, M.D. (see Reviewers page)
Revised: 9 January 2013, last major update February 2012
Copyright: (c) 2004-2013, PathologyOutlines.com, Inc.

General
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● Usually discovered incidentally or associated with anemia
● Rarely presents as liver mass
● Only very few liver nodules of EMH have been described in the literature (Diagn Cytopathol 1997;16:51)

Case reports
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● 52 year old woman with 2.5 cm, 5 cm and 7 cm liver masses and normal serum AFP (Arch Pathol Lab Med 2003;127:631)

Treatment
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● Radiation or hydroxyurea if symptomatic

Micro description
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● Erythroid precursors in sinusoids (resemble lymphocytes), myeloid precursors in portal tracts (resemble mixed portal infiltrate or eosinophils in neonates)
● Also megakaryocytes within sinuses

Micro images
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Contributed by Dr. Shilpa Jain

H&E and CD68

Cytology images
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Diff-Quick (2), Pap stain

Differential diagnosis
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● Abscess/infections
● Lymphoproliferative disorder
● Prominent megakaryocytic component may suggest atypical or malignant diagnosis

End of Liver and intrahepatic bile ducts-nontumor > Benign tumors > Extramedullary hematopoiesis

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