Liver & intrahepatic bile ducts
Benign / nonneoplastic
Extramedullary hematopoiesis

Topic Completed: 1 August 2012

Minor changes: 1 August 2020

Author: Shilpa Jain, M.D. (see Authors page)

Revised: 24 January 2019, last major update August 2012

Copyright: (c) 2002-2018,, Inc.

PubMed Search: Extramedullary hematopoiesis[TI] liver

Shilpa Jain, M.D.
Page views in 2019: 2,360
Page views in 2020 to date: 1,398
Cite this page: Jain S. Extramedullary hematopoiesis. website. Accessed August 10th, 2020.
Definition / general
  • Usually discovered incidentally or associated with anemia
  • Rarely presents as liver mass
  • Only very few liver nodules of EMH have been described in the literature (Diagn Cytopathol 1997;16:51)
Case reports
  • Radiation or hydroxyurea if symptomatic
Microscopic (histologic) description
  • Erythroid precursors in sinusoids (resemble lymphocytes), myeloid precursors in portal tracts (resemble mixed portal infiltrate or eosinophils in neonates)
  • Also megakaryocytes within sinuses
Microscopic (histologic) images

Images hosted on PathOut server:

Images contributed by Dr. S. Rajendiran, Sri Ramachandra University (India):

50 year old man with vague abdominal pain; CT abdomen showed a 2 cm mass; CT guided biopsy performed

Images hosted on other servers:

H&E and CD68

Images contributed by Dr. Nikhil Sangle, University of Utah Health Sciences Center and ARUP Laboratories:

Liver with extramedullary hematopoiesis

Cytology images

Images hosted on other servers:

Diff-Quik (2), Pap stain

Differential diagnosis
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