Liver and intrahepatic bile ducts - tumor
Other malignancies
Gastrointestinal stromal tumor (GIST)




Topic Completed: 1 February 2012

Revised: 28 January 2019, last major update February 2012

Copyright: (c) 2002-2017, PathologyOutlines.com, Inc.

PubMed Search: Gastrointestinal stromal tumor[TI] OR GIST[TI] liver[TI]

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Cite this page: Jain D. Gastrointestinal stromal tumor (GIST). PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/livertumorGIST.html. Accessed March 23rd, 2019.
Definition / general
  • Almost all cases represent metastatic GIST
  • < 10 reports of primary hepatic GIST (see below); hypothesized to originate from progenitors of mesenchymal cells capable of differentiation toward a pacemaker cell phenotype
Case reports
Gross description
  • Firm, homogenous and tan brown with necrosis
  • May have satellite nodules
Gross images

Images hosted on other servers:

Large tumor with necrotic center

Microscopic (histologic) description
  • Spindle cells arranged in short fascicles
  • Variable mitotic figures
Microscopic (histologic) images

Images hosted on other servers:

Various images


Various images (not necessarily liver)

Positive stains
Negative stains
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