Liver and intrahepatic bile ducts - tumor
Other malignancies
Gastrointestinal stromal tumor (GIST)

Author: Deepali Jain, M.D. (see Authors page)

Revised: 1 December 2017, last major update February 2012

Copyright: (c) 2002-2017, PathologyOutlines.com, Inc.

PubMed Search: Gastrointestinal stromal tumor[TI] OR GIST[TI] liver[TI]

Cite this page: Jain, D. Gastrointestinal stromal tumor (GIST). PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/livertumorGIST.html. Accessed December 16th, 2017.
Definition / general
  • Almost all cases represent metastatic GIST
  • < 10 reports of primary hepatic GIST (see below); hypothesized to originate from progenitors of mesenchymal cells capable of differentiation toward a pacemaker cell phenotype
Case reports
Gross description
  • Firm, homogenous and tan brown with necrosis
  • May have satellite nodules
Gross images

Images hosted on other servers:

Large tumor with necrotic center

Microscopic (histologic) description
  • Spindle cells arranged in short fascicles
  • Variable mitotic figures
Microscopic (histologic) images

Images hosted on other servers:

Various images


Various images (not necessarily liver)

Positive stains
Negative stains