Liver and intrahepatic bile ducts - tumor - Gastrointestinal stromal tumor (GIST)

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Liver and intrahepatic bile ducts - tumor

Other malignancies

Gastrointestinal stromal tumor (GIST)

Reviewers: Deepali Jain, M.D. (see Reviewers page)
Revised: 9 January 2013, last major update February 2012
Copyright: (c) 2004-2013, PathologyOutlines.com, Inc.

General
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● Almost all cases represent metastatic GIST
● <10 reports of primary hepatic GIST (see below); hypothesized to originate from progenitors of mesenchymal cells capable of differentiation toward a pacemaker cell phenotype

Case reports
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● 17 year boy with positive HBV (World J Gastroenterol 2009;15:3704)
● 37 year old man with lung metastases (Front Biosci 2006;11:498)
● 53 year old man with abdominal discomfort (Arch Med Sci 2012;8:392)
● 79 year old woman with malignant primary liver GIST (Arch Pathol Lab Med 2003;127:1606)

Gross description
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● Firm, homogenous and tan-brown with necrosis
● May have satellite nodules

Gross images
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Large tumor with necrotic center

Micro description
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● Spindle cells arranged in short fascicles
● Variable mitotic figures

Micro images
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Various images

Various images (not necessarily liver)

Positive stains
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● CD117, vimentin and variable CD34

Negative stains
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● Keratin, CD31, desmin, smooth muscle actin and S100

End of Liver and intrahepatic bile ducts - tumor > Other malignancies > Gastrointestinal stromal tumor (GIST)

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