Liver and intrahepatic bile ducts - tumor
Other malignancies
Gastrointestinal stromal tumor (GIST)

Topic Completed: 1 February 2012

Revised: 28 January 2019, last major update February 2012

Copyright: (c) 2002-2017,, Inc.

PubMed Search: Gastrointestinal stromal tumor[TI] OR GIST[TI] liver[TI]

Page views in 2018: 449
Page views in 2019 to date: 107
Cite this page: Jain D. Gastrointestinal stromal tumor (GIST). website. Accessed March 23rd, 2019.
Definition / general
  • Almost all cases represent metastatic GIST
  • < 10 reports of primary hepatic GIST (see below); hypothesized to originate from progenitors of mesenchymal cells capable of differentiation toward a pacemaker cell phenotype
Case reports
Gross description
  • Firm, homogenous and tan brown with necrosis
  • May have satellite nodules
Gross images

Images hosted on other servers:

Large tumor with necrotic center

Microscopic (histologic) description
  • Spindle cells arranged in short fascicles
  • Variable mitotic figures
Microscopic (histologic) images

Images hosted on other servers:

Various images

Various images (not necessarily liver)

Positive stains
Negative stains
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