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Liver and intrahepatic bile ducts - tumor

Other malignancies

Lymphoepithelioma-like carcinoma

Reviewers: Deepali Jain, M.D. (see Reviewers page)
Revised: 9 January 2013, last major update February 2012
Copyright: (c) 2004-2013, PathologyOutlines.com, Inc.


● Very rare type of hepatocellular carcinoma with pleomorphic tumor cells mixed with numerous lymphocytes; tumor cells tend to be small with focal syncytial growth; most cases are actually variant of cholangiocarcioma; usually EBV+
● Better prognosis than hepatocellular carcinoma

Case reports

● 39 year old woman with liver transplant for end stage liver disease secondary to chronic hepatitis C (Diagn Mol Pathol 2004;13:183)
● 47 year old woman with abdominal pain (World J Gastroenterol 2008;14:4694)
● 64 year old man with cirrhosis, EBV- tumor (Arch Pathol Lab Med 1999;123:441)

Micro description

● Cords and trabeculae of large polygonal epithelial cells with marked lymphocytic infiltrate
● Blurred border at tumor margin; otherwise normal liver

Micro images

Various images

Biliary tumor

Positive stains

● Keratin (CK19), EMA

Negative stains

● Vimentin, AFP, CEA, CK20, HMB4, CD30

Differential diagnosis

Cholangiocarcinoma-lymphoepithelioma like variant: syncytial pattern of undifferentiated epithelial cells and glands in lymphocyte-plasma cell rich stroma; presence of glands differentiates this from lymphoepithelioma-like carcinoma

End of Liver and intrahepatic bile ducts - tumor > Other malignancies > Lymphoepithelioma-like carcinoma

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