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Liver and intrahepatic bile ducts - tumor

Other malignancies

Leiomyosarcoma


Reviewers: Deepali Jain, M.D. (see Reviewers page)
Revised: 9 January 2013, last major update February 2012
Copyright: (c) 2004-2013, PathologyOutlines.com, Inc.

General
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● Rare (<30 cases reported) aggressive malignant smooth muscle neoplasm, usually post-menopausal women, characterized by neoplastic spindle cells (WHO)
● Tumors either primary in liver or arise in ligamentum teres or inferior vena cava
● Associated with HIV, post-transplantation in children and Budd-Chiari syndrome
● Usually causes death within 2 years

Case reports
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● Child with congenital immunodeficiency and multifocal EBV+ leiomyosarcoma involving liver, thyroid and lung (Am J Surg Pathol 1999;23:473)
● 26 year old man with EBV+ leiomyosarcoma post-cardiac transplant (Am J Surg Pathol 2000;24:614)
● 34 year old HIV+ man with multiple EBV+ tumors (Am J Surg Pathol 2000;24:614)

Micro images
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67 year old man

Micro images
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Liver metastases of rectal carcinoma (left) and primary hepatic leiomyosarcoma (right)


67 year old man with 1.3 kg mass

Differential diagnosis
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Epithelioid hemangioendothelioma

End of Liver and intrahepatic bile ducts - tumor > Other malignancies > Leiomyosarcoma


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