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Liver and intrahepatic bile ducts - tumor

Other malignancies


Reviewers: Deepali Jain, M.D. (see Reviewers page)
Revised: 9 January 2013, last major update February 2012
Copyright: (c) 2004-2013, PathologyOutlines.com, Inc.


● Rare (<30 cases reported) aggressive malignant smooth muscle neoplasm, usually post-menopausal women, characterized by neoplastic spindle cells (WHO)
● Tumors either primary in liver or arise in ligamentum teres or inferior vena cava
● Associated with HIV, post-transplantation in children and Budd-Chiari syndrome
● Usually causes death within 2 years

Case reports

● Child with congenital immunodeficiency and multifocal EBV+ leiomyosarcoma involving liver, thyroid and lung (Am J Surg Pathol 1999;23:473)
● 26 year old man with EBV+ leiomyosarcoma post-cardiac transplant (Am J Surg Pathol 2000;24:614)
● 34 year old HIV+ man with multiple EBV+ tumors (Am J Surg Pathol 2000;24:614)

Micro images

67 year old man

Micro images

Liver metastases of rectal carcinoma (left) and primary hepatic leiomyosarcoma (right)

67 year old man with 1.3 kg mass

Differential diagnosis

Epithelioid hemangioendothelioma

End of Liver and intrahepatic bile ducts - tumor > Other malignancies > Leiomyosarcoma

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