Liver and intrahepatic bile ducts - tumor
Leukemia / lymphoma
Mucosal associated lymphoid tissue (MALT) lymphoma

Topic Completed: 1 February 2012

Revised: 7 August 2019

Copyright: 2002-2019,, Inc.

PubMed Search: Mucosal associated lymphoid tissue[TI] OR MALT[TI] lymphoma liver

See also: Lymphoma and plasma cell neoplasms chapter

Deepali Jain, M.D.
Page views in 2018: 203
Page views in 2019 to date: 174
Cite this page: Jain D. Mucosal associated lymphoid tissue (MALT) lymphoma. website. Accessed December 9th, 2019.
Definition / general
  • Rare, < 50 cases reported; represents 3% of cases of hepatic lymphoma (Int J Hematol 2008;88:418)
  • Mean age 60 years, slight female predominance
  • Occasionally associated with liver cirrhosis, primary biliary cirrhosis, hepatitis B and hepatitis C infection
Case reports
  • Local excision; tumor is indolent
Gross images

Images hosted on other servers:

Solitary or multiple tan, subcapsular nodule

Microscopic (histologic) description
  • Extensive diffuse sheets of small B cells in the interfollicular areas
  • Centrocyte-like cells surround reactive B cell follicles and form lymphoepithelial lesions with bile ducts (Am J Surg Pathol 1995;19:571, Mod Pathol 1998;11:404)
  • May arise in settings of chronic inflammation including viral hepatitis
  • Note: reactive follicles and lymphoepithelial lesions are nonspecific
Microscopic (histologic) images

Images hosted on other servers:

Entrapping bile ducts


entrapping islands
of hepatocytes

Various images

Molecular / cytogenetics description
  • t(11;18)(q21;q21), t(1;14)(p22;q23), t(14;18)(q32;q21), 37 and t(3;14)(p14.1;q32)
Differential diagnosis
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