Liver and intrahepatic bile ducts - tumor
Other malignancies
Neuroendocrine carcinoma

Author: Deepali Jain, M.D. (see Authors page)

Revised: 5 December 2017, last major update February 2012

Copyright: (c) 2002-2017,, Inc.

PubMed Search: Neuroendocrine carcinoma[TI] liver[TI]

Cite this page: Jain, D. Neuroendocrine carcinoma. website. Accessed December 14th, 2018.
Definition / general
  • < 100 cases reported; mean age > 40 years, more common in women (Arch Pathol Lab Med 2003;127:1200)
  • Normal serum AFP but high serum NSE, chromogranin and synaptophysin levels
  • Not associated with chronic liver disease / cirrhosis
  • Presents with diarrhea and abdominal pain
  • Amphicrine carcinoma: glandular (signet ring morphology, mucicarmine, PASD+, villin+, CDX2+) and neuroendocrine differentiation in same cells (Ann Diagn Pathol 2011;15:355)
Case reports
Gross description
  • Typically solitary, may be cystic
Microscopic (histologic) description
  • Resembles poorly differentiated carcinomas with cellular pleomorphism, nuclear atypia, hyperchromasia and frequent mitotic figures
  • May have signet ring morphology with intracytoplasmic vacuoles negative for mucin but positive for neuroendocrine markers (Semin Liver Dis 2010;30:422)
Microscopic (histologic) images

Images hosted on other servers:

H&E and chromogranin (figures C / D)

Positive stains
Electron microscopy description
  • Dense core granules
Differential diagnosis
  • Carcinoid tumor: low (< 2/10 HPF) mitotic activity, minimal nuclear polymorphism