Liver and intrahepatic bile ducts - tumor
Benign tumors / conditions
Solitary fibrous tumor

Topic Completed: 1 February 2012

Revised: 25 January 2019, last major update February 2012

Copyright: (c) 2002-2017,, Inc.

PubMed Search: Solitary fibrous tumor[TI] liver

Deepali Jain, M.D.
Page views in 2019: 434
Page views in 2020 to date: 94
Cite this page: Jain D. Solitary fibrous tumor. website. Accessed February 27th, 2020.
Definition / general
  • Also called localized fibrous tumor / localized fibrous mesothelioma
  • Rare; fewer than 40 reported cases in liver; may arise from beneath liver capsule
  • Predominantly occur in women (2:1); age range 27 - 83 years
  • Associated with hypoglycemia
Case reports
  • Complete surgical resection with long term follow up
Gross description
  • Solitary mass, well circumscribed, encapsulated, often 15 cm or more, with bulging, solid, gray white cut surface, highly vascular
Microscopic (histologic) description
  • Patternless architecture, alternating hypocellular and hypercellular areas
  • Spindle cells without atypia mixed with hyalinized collagen
  • Mild atypia; rare mitotic figures; no necrosis
  • Criteria for malignancy: high cellularity and mitotic activity (> 4/10 HPF), pleomorphism, necrosis and local invasion
Microscopic (histologic) images

Images hosted on other servers:

H&E and CD34

Positive stains
Differential diagnosis
Back to top