Liver and intrahepatic bile ducts - tumor
Benign tumors / conditions
Atypical bile duct adenoma, clear cell type

Author: Deepali Jain, M.D. (see Authors page)

Revised: 15 November 2017, last major update February 2012

Copyright: (c) 2002-2017,, Inc.

PubMed Search: Atypical bile duct adenoma

See also: Bile duct adenoma
Page views in 2018: 137
Page views in 2019 to date: 148
Cite this page: Jain, D. Atypical bile duct adenoma, clear cell type. website. Accessed December 11th, 2019.
Definition / general
  • Rare; ages 25 - 63 years in 3 cases described (Am J Surg Pathol 2001;25:956)
  • Incidental finding
  • Cytoplasmic clearing may be due to accumulation of fat, acid mucin or distended endoplasmic reticulum
Gross description
  • 1 cm, subcapsular
Microscopic (histologic) description
  • Bile duct tumor composed almost entirely of small nests and tubules of clear cells infiltrating hepatic parenchyma by involving entrapped normal bile ducts; small nests surrounded by PAS+ membrane (may represent tubular structures)
  • Well defined cytoplasmic borders, mild nuclear hyperchromasia, mild stromal sclerosis; no mitotic activity
Positive stains
Negative stains
Differential diagnosis
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